Brian P. Anton

TL;DR: Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units.

TL;DR: This study shows that the addition of SMRT sequencing to traditional sequencing approaches gives a wealth of useful functional information about a genome showing not only which MTase genes are active but also revealing their recognition sequences.

TL;DR: This community page discusses the progress made by the COMBREX project to address this important issue using both computational and experimental resources.

TL;DR: The results suggest that T. turnerae is likely a facultative intracellular ensosymbiont whose niche presently includes, or recently included, free-living existence.

TL;DR: The comprehensive methylomes of two H. pylori strains are determined at single base resolution using Single Molecule Real-Time (SMRT®) sequencing and revealed novel features of both Type I and Type II R-M systems, including frameshift-mediated changes of sequence specificity and the interaction of one MTase with two alternative specificity subunits resulting in different methylation patterns.