Matthew Boitano

TL;DR: A greater complexity of the human genome in the form of variation of longer and more complex repetitive DNA that can now be largely resolved with the application of this longer-read sequencing technology is suggested.

TL;DR: It is asserted that the collected updates in GRCh38 make the newer assembly a more robust substrate for comprehensive analyses that will promote the understanding of human biology and advance the efforts to improve health.

TL;DR: Interestingly, when the authors repeat SV detection on a pseudodiploid genome constructed in silico by merging the two haploids, it is found that ∼59% of the heterozygous SVs are no longer detected by SMRT-SV, indicating that haploid resolution of long-read sequencing data will significantly increase sensitivity of SV detection.

TL;DR: A new DNA sequencing method is used to take a close look at one way in which antibiotic resistance spreads, and finds evidence that plasmids carrying carbapenemase genes moved from one microbial species to another within the hospital environment.

TL;DR: SMRT sequencing confirms the identity and position of the methylated base in cases where the MTase specificity was previously established by other methods and finds evidence of unanticipated MTase promiscuity with some enzymes apparently also modifying sequences that are related, but not identical to the cognate site.