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Brian Wigdahl
Researcher at Drexel University
Publications - 229
Citations - 6653
Brian Wigdahl is an academic researcher from Drexel University. The author has contributed to research in topics: Virus & Long terminal repeat. The author has an hindex of 41, co-authored 215 publications receiving 5987 citations. Previous affiliations of Brian Wigdahl include Thomas Jefferson University & Pennsylvania State University.
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Cellular Reservoirs of HIV-1 and their Role in Viral Persistence
TL;DR: Cell populations of the monocyte-macrophage lineage, which originate in the bone marrow, are of particular importance in HIV-1 persistence due to their ability to cross the blood-brain barrier and spread HIV- 1 infection in the immunoprivileged central nervous system (CNS).
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Antiviral Potentials of Medicinal Plants
Muhammad Mukhtar,Mohammad Arshad,Mahmood Ahmad,Roger J. Pomerantz,Brian Wigdahl,Zahida Parveen +5 more
TL;DR: Potential antiviral properties of medicinal plants against a diverse group of viruses are described, and screening the potential of plants possessing broad-spectrum antiviral effects against emerging viral infections is suggested.
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CD4-independent infection of human neural cells by human immunodeficiency virus type 1.
Janet M. Harouse,C Kunsch,H T Hartle,Mark A. Laughlin,James A. Hoxie,Brian Wigdahl,Francisco Gonzalez-Scarano +6 more
TL;DR: The results indicate that CD4 is not the receptor for HIV-1 infection of the glioblastoma line U373-MG, medulloblastomas line MED 217, or primary human fetal neural cells.
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Breaking Down the Barrier: The effects of HIV-1 on the Blood-Brain Barrier
TL;DR: It is proposed in this review that the dysregulation of the BBB during and after neuroinvasion is a critical component of the neuropathogenic process and that Dysregulation of this protective barrier is caused by a combination of viral and host factors including secreted viral proteins, components of the inflammatory process, the aging process, therapeutics, and drug or alcohol abuse.
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HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination
Aikaterini Alexaki,Brian Wigdahl +1 more
TL;DR: Changes in the growth and differentiation process of HPCs may be involved in the generation of monocyte populations that are more susceptible and/or permissive to HIV-1, and have potentially altered trafficking profiles to several organs, including the CNS.