S
Stephen Yip
Researcher at University of British Columbia
Publications - 194
Citations - 8291
Stephen Yip is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 37, co-authored 158 publications receiving 6539 citations. Previous affiliations of Stephen Yip include Sanford-Burnham Institute for Medical Research & Harvard University.
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Journal ArticleDOI
ARID1A mutations in endometriosis-associated ovarian carcinomas.
Kimberly C. Wiegand,Sohrab P. Shah,Osama M. Al-Agha,Yongjun Zhao,Kane Tse,Thomas Zeng,Janine Senz,Melissa K. McConechy,Michael S. Anglesio,Steve E. Kalloger,Winnie Yang,Alireza Heravi-Moussavi,Ryan Giuliany,Christine Chow,John Fee,Abdalnasser Zayed,Leah M Prentice,Nataliya Melnyk,Gulisa Turashvili,Allen Delaney,Jason Madore,Stephen Yip,Andrew McPherson,Gavin Ha,Lynda Bell,Sian Fereday,Angela Tam,Laura Galletta,Patricia N. Tonin,Diane Provencher,Dianne Miller,Steven J.M. Jones,Richard A. Moore,Gregg B. Morin,Gregg B. Morin,Arusha Oloumi,Niki Boyd,Samuel Aparicio,Ie Ming Shih,Anne Marie Mes-Masson,David D.L. Bowtell,David D.L. Bowtell,Martin Hirst,Blake Gilks,Marco A. Marra,Marco A. Marra,David G. Huntsman +46 more
TL;DR: These data implicate ARID1A as a tumor-suppressor gene frequently disrupted in ovarian clear-cell and endometrioid carcinomas.
Journal ArticleDOI
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Kathryn R. Taylor,Alan Mackay,Nathalene Truffaux,Yaron S. Butterfield,Olena Morozova,Olena Morozova,Cathy Philippe,David Castel,Catherine S. Grasso,Maria Vinci,Diana Carvalho,Angel M. Carcaboso,Carmen de Torres,Ofelia Cruz,Jaume Mora,Natacha Entz-Werle,Wendy J. Ingram,Michelle Monje,Darren Hargrave,Alex N. Bullock,Stéphanie Puget,Stephen Yip,Chris Jones,Jacques Grill +23 more
TL;DR: The identification of recurrent activating mutations in the ACVR1 gene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples are reported, which represent new targets for therapeutic intervention in this otherwise incurable disease.
Journal ArticleDOI
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
Ali Bashashati,Gavin Ha,Alicia A. Tone,Jiarui Ding,Jiarui Ding,Leah M Prentice,Andrew Roth,Jamie Rosner,Karey Shumansky,Steve E. Kalloger,Janine Senz,Winnie Yang,Melissa K. McConechy,Nataliya Melnyk,Michael S. Anglesio,Margaret Luk,Kane Tse,Thomas Zeng,Richard A. Moore,Yongjun Zhao,Marco A. Marra,Blake Gilks,Stephen Yip,David G. Huntsman,David G. Huntsman,Jessica N. McAlpine,Sohrab P. Shah,Sohrab P. Shah +27 more
TL;DR: The results revealed that HGSCs exhibit highly individual evolutionary trajectories and diverse genomic tapestries prior to therapy, exposing an essential biological characteristic to inform future design of personalized therapeutic solutions and investigation of drug‐resistance mechanisms.
Journal ArticleDOI
MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance
Stephen Yip,Jiangyong Miao,Daniel P. Cahill,A. John Iafrate,Kenneth Aldape,Catherine L. Nutt,David N. Louis +6 more
TL;DR: MSH6 mutations are selected in glioblastomas during temozolomide therapy both in vitro and in vivo and are causally associated with temozlomide resistance.
Journal ArticleDOI
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.
Stephen Yip,Yaron S. Butterfield,Olena Morozova,Suganthi Chittaranjan,Michael D. Blough,Jianghong An,Inanc Birol,Charles Chesnelong,Readman Chiu,Eric Chuah,Richard Corbett,Rod Docking,Marlo Firme,Martin Hirst,Shaun D. Jackman,Aly Karsan,Haiyan Li,David N. Louis,Alexandra Maslova,Richard A. Moore,Annie Moradian,Karen Mungall,Marco Perizzolo,Jenny Q. Qian,Gloria Roldán,Eric E. Smith,Jessica Tamura-Wells,Nina Thiessen,Richard Varhol,Samuel Weiss,Wei Wu,Sean D. Young,Yongjun Zhao,Andrew J. Mungall,Steven J.M. Jones,Gregg B. Morin,Jennifer A. Chan,J. Gregory Cairncross,Marco A. Marra,Marco A. Marra +39 more
TL;DR: It is hypothesized that the mutant CIC on the single retained 19q allele is linked to the pathogenesis of oligodendrogliomas with IDH mutation, and in a background of 1p/19q co‐deletion, hemizygous CIC mutations are likely important.