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Camila A. Orellana
Researcher at University of Queensland
Publications - 15
Citations - 925
Camila A. Orellana is an academic researcher from University of Queensland. The author has contributed to research in topics: Chinese hamster ovary cell & Clostridium. The author has an hindex of 11, co-authored 15 publications receiving 752 citations. Previous affiliations of Camila A. Orellana include University of Chile & Pontifical Catholic University of Chile.
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Journal ArticleDOI
Recon 2.2: from reconstruction to model of human metabolism
Neil Swainston,Kieran Smallbone,Hooman Hefzi,Paul D. Dobson,Judy Brewer,Michael Hanscho,Daniel C. Zielinski,Kok Siong Ang,Natalie J. Gardiner,Jahir M. Gutierrez,Sarantos Kyriakopoulos,Meiyappan Lakshmanan,Shangzhong Li,Joanne K. Liu,Veronica Martinez,Camila A. Orellana,Lake-Ee Quek,Alex Thomas,Juergen Zanghellini,Nicole Borth,Dong-Yup Lee,Dong-Yup Lee,Lars K. Nielsen,Douglas B. Kell,Nathan E. Lewis,Pedro Mendes +25 more
TL;DR: The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes as discussed by the authors, and since the last community effort generated a consensus reconstruction, several updates have been developed.
Journal Article
Recon 2.2: from reconstruction to model of human metabolism
Neil Swainston,Kieran Smallbone,Hooman Hefzi,Paul D. Dobson,Judy Brewer,Michael Hanscho,Daniel C. Zielinski,Kok Siong Ang,Natalie J. Gardiner,Jahir M. Gutierrez,Sarantos Kyriakopoulos,Meiyappan Lakshmanan,Shangzhong Li,Joanne K. Liu,Veronica Martinez,Camila A. Orellana,Lake-Ee Quek,Alex Thomas,Juergen Zanghellini,Nicole Borth,Dong-Yup Lee,Dong-Yup Lee,Lars K. Nielsen,Douglas B. Kell,Nathan E. Lewis,Pedro Mendes +25 more
TL;DR: Through updates, the most complete and best annotated consensus human metabolic reconstruction available is achieved, thereby increasing the ability of this resource to provide novel insights into normal and disease states in human.
Journal ArticleDOI
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.
Hooman Hefzi,Kok Siong Ang,Michael Hanscho,Aarash Bordbar,David E. Ruckerbauer,Meiyappan Lakshmanan,Camila A. Orellana,Deniz Baycin-Hizal,Yingxiang Huang,Daniel Ley,Veronica Martinez,Sarantos Kyriakopoulos,Natalia E Jiménez,Daniel C. Zielinski,Lake-Ee Quek,Tune Wulff,Johnny Arnsdorf,Shangzhong Li,Jae Seong Lee,Giuseppe Paglia,Nicolás Loira,Philipp Spahn,Lasse Ebdrup Pedersen,Jahir M. Gutierrez,Zachary A. King,Anne Mathilde Lund,Harish Nagarajan,Alex Thomas,Alyaa M. Abdel-Haleem,Juergen Zanghellini,Helene Faustrup Kildegaard,Bjørn G. Voldborg,Ziomara P. Gerdtzen,Michael J. Betenbaugh,Bernhard O. Palsson,Mikael Rørdam Andersen,Lars K. Nielsen,Nicole Borth,Dong-Yup Lee,Dong-Yup Lee,Nathan E. Lewis +40 more
TL;DR: The models accurately predict growth phenotypes and known auxotrophies in CHO cells and show that the metabolic resources in CHO are more than three times more efficiently utilized for growth or recombinant protein synthesis following targeted efforts to engineer the CHO secretory pathway.
Journal ArticleDOI
High-Antibody-Producing Chinese Hamster Ovary Cells Up-Regulate Intracellular Protein Transport and Glutathione Synthesis
Camila A. Orellana,Esteban Marcellin,Benjamin L. Schulz,Amanda Nouwens,Peter P. Gray,Lars K. Nielsen +5 more
TL;DR: Two biological processes were identified as differentially regulated by both methods: up-regulation of glutathione biosynthesis and down- regulation of DNA replication, which may be important for conferring high mAb production and as such are promising candidates for targeted engineering of high-expression cell lines.
Journal ArticleDOI
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update.
Pablo Cruz-Morales,Pablo Cruz-Morales,Camila A. Orellana,George Moutafis,Glenn Moonen,Gonzalo Rincon,Lars K. Nielsen,Esteban Marcellin +7 more
TL;DR: The analysis shows that the current taxonomic classification of Clostridium species hinders the prediction of functions and traits, suggests a new classification for this fascinating class of bacteria, and highlights the importance of phylogenomics for taxonomic studies.