C
Carles Cantó
Researcher at Nestlé
Publications - 88
Citations - 16810
Carles Cantó is an academic researcher from Nestlé. The author has contributed to research in topics: NAD+ kinase & Skeletal muscle. The author has an hindex of 46, co-authored 79 publications receiving 14037 citations. Previous affiliations of Carles Cantó include École Polytechnique Fédérale de Lausanne & University of Barcelona.
Papers
More filters
Journal ArticleDOI
AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity
Carles Cantó,Zachary Gerhart-Hines,Jerome N. Feige,Marie Lagouge,Liliana Noriega,Liliana Noriega,Jill C. Milne,Peter J. Elliott,Pere Puigserver,Johan Auwerx,Johan Auwerx +10 more
TL;DR: It is demonstrated that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1.
Journal ArticleDOI
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure.
Carles Cantó,Johan Auwerx +1 more
TL;DR: Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic homeostasis and understanding the mechanisms by which they act could guide us to identify and improve preventive and therapeutic strategies for metabolic diseases.
Journal ArticleDOI
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.
TL;DR: This review summarizes how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
Journal ArticleDOI
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud,Riekelt H. Houtkooper,Norman Moullan,Elena Katsyuba,Dongryeol Ryu,Carles Cantó,Adrienne Mottis,Young Suk Jo,Mohan Viswanathan,Kristina Schoonjans,Leonard Guarente,Johan Auwerx +11 more
TL;DR: The data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline.
Journal ArticleDOI
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity
Carles Cantó,Riekelt H. Houtkooper,Eija Pirinen,Eija Pirinen,Dou Yeon Youn,Maaike H. Oosterveer,Yana Cen,Pablo J. Fernandez-Marcos,Hiroyasu Yamamoto,Pénélope Andreux,Philippe Cettour-Rose,Karl Gademann,Chris Rinsch,Kristina Schoonjans,Anthony A. Sauve,Johan Auwerx +15 more
TL;DR: It is shown that NR supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.