NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.
TLDR
This review summarizes how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.About:
This article is published in Cell Metabolism.The article was published on 2015-07-07 and is currently open access. It has received 1061 citations till now. The article focuses on the topics: Mitochondrial unfolded protein response & NAD+ kinase.read more
Citations
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Journal ArticleDOI
The Mitochondrial Basis of Aging
TL;DR: It is suggested that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.
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NAD+ in aging, metabolism, and neurodegeneration
TL;DR: Factors that regulate NAD+ and how supplementation with NAD+ precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases are reviewed.
Journal ArticleDOI
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang,Dongryeol Ryu,Yibo Wu,Karim Gariani,Xu Wang,Peiling Luan,Davide D'Amico,Eduardo R. Ropelle,Eduardo R. Ropelle,Matthias P. Lutolf,Ruedi Aebersold,Ruedi Aebersold,Kristina Schoonjans,Keir J. Menzies,Keir J. Menzies,Johan Auwerx +15 more
TL;DR: It is demonstrated the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence and it is demonstrated that NR delays senescences of neural SCs and melanocyteSCs and increases mouse life span.
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Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
TL;DR: The modulation of tryptophan-kynurenine metabolism using lifestyle and pharmacological interventions could help prevent and treat several diseases with underlying inflammatory mechanisms, including metabolic, oncologic, and mental health disorders.
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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
TL;DR: A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health.
References
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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