K
Karey Shumansky
Researcher at BC Cancer Agency
Publications - 15
Citations - 3034
Karey Shumansky is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Germline mutation & Follicular lymphoma. The author has an hindex of 11, co-authored 15 publications receiving 2556 citations.
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Journal ArticleDOI
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
Peter Eirew,Peter Eirew,Adi Steif,Adi Steif,Jaswinder Khattra,Jaswinder Khattra,Gavin Ha,Gavin Ha,Damian Yap,Damian Yap,Hossein Farahani,Hossein Farahani,Karen A. Gelmon,Stephen Chia,Colin Mar,Adrian Wan,Emma Laks,Emma Laks,Justina Biele,Justina Biele,Karey Shumansky,Jamie Rosner,Andrew McPherson,Andrew McPherson,Cydney B. Nielsen,Cydney B. Nielsen,Andrew Roth,Andrew Roth,Calvin Lefebvre,Calvin Lefebvre,Ali Bashashati,Ali Bashashati,Camila P. E. de Souza,Celia Siu,Radhouane Aniba,Radhouane Aniba,Jazmine Brimhall,Arusha Oloumi,Arusha Oloumi,Tomo Osako,Tomo Osako,Alejandra Bruna,José Luis Sandoval,Teresa Ruiz de Algara,Teresa Ruiz de Algara,Wendy Greenwood,Kaston Leung,Hongwei Cheng,Hongwei Cheng,Hui Xue,Hui Xue,Yuzhuo Wang,Yuzhuo Wang,Dong Lin,Dong Lin,Andrew J. Mungall,Richard D. Moore,Yongjun Zhao,Julie Lorette,Long V. Nguyen,Long V. Nguyen,David G. Huntsman,David G. Huntsman,Connie J. Eaves,Connie J. Eaves,Carl L. Hansen,Marco A. Marra,Carlos Caldas,Sohrab P. Shah,Sohrab P. Shah,Samuel Aparicio +70 more
TL;DR: The results show that measurement of genomically defined clonal population dynamics will be highly informative for functional studies using patient-derived breast cancer xenoengraftment, and indicates that genomic aberrations can be reproducible determinants of evolutionary trajectories.
Journal ArticleDOI
Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond
Samantha Hansford,Pardeep Kaurah,Hector Li-Chang,Michelle M.M. Woo,Janine Senz,Hugo Pinheiro,Kasmintan A. Schrader,David F. Schaeffer,Karey Shumansky,George Zogopoulos,Teresa Almeida Santos,Isabel Claro,Joana Carvalho,Cydney B. Nielsen,Sarah Padilla,Amy Lum,Aline Talhouk,Katie Baker-Lange,Susan Richardson,Ivy Lewis,Noralane M. Lindor,Erin Pennell,Andrée MacMillan,Bridget A. Fernandez,G. Keller,Henry T. Lynch,Sohrab P. Shah,Parry Guilford,Steven Gallinger,Giovanni Corso,Franco Roviello,Carlos Caldas,Carla Oliveira,Paul D.P. Pharoah,David G. Huntsman +34 more
TL;DR: HGC syndrome may be best defined by mutations in CDH1 and closely related genes, rather than through clinical criteria that capture families with heterogeneous susceptibility profiles, providing more precise estimates of age-associated risks of gastric and breast cancer that will improve counseling of unaffected carriers.
Journal ArticleDOI
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
Ali Bashashati,Gavin Ha,Alicia A. Tone,Jiarui Ding,Jiarui Ding,Leah M Prentice,Andrew Roth,Jamie Rosner,Karey Shumansky,Steve E. Kalloger,Janine Senz,Winnie Yang,Melissa K. McConechy,Nataliya Melnyk,Michael S. Anglesio,Margaret Luk,Kane Tse,Thomas Zeng,Richard A. Moore,Yongjun Zhao,Marco A. Marra,Blake Gilks,Stephen Yip,David G. Huntsman,David G. Huntsman,Jessica N. McAlpine,Sohrab P. Shah,Sohrab P. Shah +27 more
TL;DR: The results revealed that HGSCs exhibit highly individual evolutionary trajectories and diverse genomic tapestries prior to therapy, exposing an essential biological characteristic to inform future design of personalized therapeutic solutions and investigation of drug‐resistance mechanisms.
Journal ArticleDOI
TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data
Gavin Ha,Gavin Ha,Andrew Roth,Andrew Roth,Jaswinder Khattra,Julie Ho,Damian Yap,Leah M Prentice,Nataliya Melnyk,Andrew McPherson,Andrew McPherson,Ali Bashashati,Emma Laks,Justina Biele,Jiarui Ding,Jiarui Ding,Alan Le,Jamie Rosner,Karey Shumansky,Marco A. Marra,C. Blake Gilks,David G. Huntsman,Jessica N. McAlpine,Samuel Aparicio,Samuel Aparicio,Sohrab P. Shah,Sohrab P. Shah +26 more
TL;DR: A novel probabilistic model is presented, TITAN, to infer CNA and LOH events while accounting for mixtures of cell populations, thereby estimating the proportion of cells harboring each event.
Journal ArticleDOI
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer
Andrew McPherson,Andrew Roth,Andrew Roth,Emma Laks,Tehmina Masud,Tehmina Masud,Ali Bashashati,Allen W. Zhang,Allen W. Zhang,Allen W. Zhang,Gavin Ha,Justina Biele,Damian Yap,Adrian Wan,Leah M Prentice,Jaswinder Khattra,Maia A. Smith,Maia A. Smith,Cydney B. Nielsen,Sarah C. Mullaly,Steve E. Kalloger,Anthony N. Karnezis,Karey Shumansky,Celia Siu,Jamie Rosner,Hector Li Chan,Julie Ho,Nataliya Melnyk,Janine Senz,Winnie Yang,Richard A. Moore,Andrew J. Mungall,Marco A. Marra,Alexandre Bouchard-Côté,C. Blake Gilks,David G. Huntsman,David G. Huntsman,Jessica N. McAlpine,Samuel Aparicio,Samuel Aparicio,Sohrab P. Shah,Sohrab P. Shah +41 more
TL;DR: It is indicated that at least two distinct modes of intraperitoneal spread operate in clonal dissemination and highlight the distribution of migratory potential over clonal populations comprising high-grade serous ovarian cancers.