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Carlos Lamsfus Calle
Researcher at University of Tübingen
Publications - 11
Citations - 686
Carlos Lamsfus Calle is an academic researcher from University of Tübingen. The author has contributed to research in topics: Malaria & Malaria vaccine. The author has an hindex of 5, co-authored 9 publications receiving 442 citations.
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Journal ArticleDOI
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine
Benjamin Mordmüller,Güzin Surat,Heimo Lagler,Heimo Lagler,Sumana Chakravarty,Andrew S. Ishizuka,Albert Lalremruata,Markus Gmeiner,Joseph J. Campo,Meral Esen,Adam Ruben,Jana Held,Carlos Lamsfus Calle,Juliana Boex Mengue,Tamirat Gebru,Javier Ibáñez,Mihály Sulyok,Eric R. James,Peter F. Billingsley,Natasha Kc,Anita Manoj,Tooba Murshedkar,Anusha Gunasekera,Abraham G. Eappen,Tao Li,Richard E. Stafford,Minglin Li,Phil Felgner,Robert A. Seder,Thomas L. Richie,B. Kim Lee Sim,Stephen L. Hoffman,Peter G. Kremsner +32 more
TL;DR: PfSPZ-CVac is a highly efficacious vaccine candidate that could be used for combination mass drug administration and a mass vaccination program approach to eliminate malaria from geographically defined areas when able to optimize the immunization regimen.
Journal ArticleDOI
Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres
Benjamin Mordmüller,Christian Supan,Kim Lee Sim,Gloria P Gómez-Pérez,Carmen L. Ospina Salazar,Jana Held,Stefanie Bolte,Meral Esen,Serena Tschan,Fanny Joanny,Carlos Lamsfus Calle,Sascha J Z Löhr,Albert Lalremruata,Anusha Gunasekera,Eric R. James,Peter F. Billingsley,Adam D. Richman,Sumana Chakravarty,Almudena Legarda,Jose Muñoz,Rosa M. Antonijoan,Maria Ballester,Stephen L. Hoffman,Pedro L. Alonso,Peter G. Kremsner +24 more
TL;DR: IV inoculation of PfSPZ is safe, well tolerated and highly reproducible, and shall further accelerate development of anti-malarial interventions through standardization and facilitation of CHMI.
Journal ArticleDOI
First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria.
Benjamin Mordmüller,Mihály Sulyok,Diane Egger-Adam,Mafalda Resende,Willem A. de Jongh,Mette H Jensen,Helle Holm Smedegaard,Sisse B. Ditlev,Max Soegaard,Lars Poulsen,Charlotte Dyring,Carlos Lamsfus Calle,Annette Knoblich,Javier Ibáñez,Meral Esen,Philippe Deloron,Nicaise Tuikue Ndam,Saadou Issifou,Sophie Houard,Randall F. Howard,Steven G. Reed,Odile Leroy,Adrian J. F. Luty,Thor G. Theander,Peter G. Kremsner,Ali Salanti,Morten Nielsen +26 more
TL;DR: PAMVAC formulated with Alhydrogel or GLA-based adjuvants was safe, well-tolerated and induced functionally active antibodies, which will be assessed in women before first pregnancies in an endemic area.
Journal ArticleDOI
DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection
Mihály Sulyok,Thomas Rückle,Alexandra Roth,Raymund E. Mürbeth,Stephan Chalon,Nicola Kerr,Sonia Schnieper Samec,Nathalie Gobeau,Carlos Lamsfus Calle,Javier Ibáñez,Zita Sulyok,Jana Held,Tamirat Gebru,Patricia Granados,Sina Brückner,Christian N. Nguetse,Juliana Boex Mengue,Albert Lalremruata,B. Kim Lee Sim,Stephen L. Hoffman,Jörg J. Möhrle,Peter G. Kremsner,Benjamin Mordmüller +22 more
TL;DR: A single dose of 400 mg DSM265 was well tolerated and had causal prophylactic activity when given 1 day before CHMI, and the primary efficacy endpoint was time-to-parasitaemia, assessed by TBS.
Journal ArticleDOI
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial.
Zita Sulyok,Rolf Fendel,Bianca Eder,Freia-Raphaella Lorenz,Natasha Kc,Matthias Karnahl,Albert Lalremruata,Jana Held,Folashade Almeine Cyntiche Adjadi,Torsten Klockenbring,Judith Flügge,Tamirat Gebru Woldearegai,Carlos Lamsfus Calle,Javier Ibáñez,Miriam Rodi,Diane Egger-Adam,Andrea Kreidenweiss,Carsten Köhler,Meral Esen,Mihály Sulyok,Anita Manoj,Thomas L. Richie,B. Kim Lee Sim,Stephen L. Hoffman,Benjamin Mordmüller,Benjamin Mordmüller,Peter G. Kremsner +26 more
TL;DR: A double-blinded, randomized, placebo-controlled trial of a simplified, condensed immunization regimen in malaria-naive volunteers (EudraCT-Nr: 2018-004523-36) is reported in this paper.