Luciana Ansaneli Naves

TL;DR: Prisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.

TL;DR: AIP mutations, of which nine new mutations have been described here, occur in approximately 15% of FIPA families, and although pituitary tumors occurring in association with AIP mutations are predominantly somatotropinomas, other tumor types are also seen.

TL;DR: A pediatric disorder is described that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone.

TL;DR: The typical coarsening of facial features include furrowing of fronthead, pronounced brow protrusion, enlargement of the nose and the ears, thickening of the lips, skin wrinkles and nasolabial folds, as well as mandibular prognathism that leads to dental malocclusion and increased interdental spacing.

TL;DR: Down-regulation of AIP and AHR may be involved in the aggressiveness of somatotrophinomas and data obtained on AHR expression suggest that AHR signalling may be differentially affected according to PA phenotype.