T
Timo Sane
Researcher at University of Helsinki
Publications - 84
Citations - 4641
Timo Sane is an academic researcher from University of Helsinki. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 39, co-authored 84 publications receiving 4339 citations. Previous affiliations of Timo Sane include Helsinki University Central Hospital.
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Journal ArticleDOI
Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas: An International Collaborative Study
Adrian Daly,Maria A. Tichomirowa,Patrick Petrossians,Elina Heliövaara,Marie Lise Jaffrain-Rea,Anne Barlier,Luciana Ansaneli Naves,Tapani Ebeling,Auli Karhu,Antti Raappana,Laure Cazabat,Ernesto De Menis,Carmen Fajardo Montañana,Gérald Raverot,Robert J. Weil,Timo Sane,Dominique Maiter,Sebastian J C M M Neggers,Maria Yaneva,AntoineAntoine Tabarin,Elisa Verrua,Eija Eloranta,Arnaud Murat,Outi Vierimaa,Pasi I. Salmela,Philippe Emy,Rodrigo A. Toledo,Maria Isabel Sabaté,Chiara Villa,Chiara Villa,Marc Popelier,Roberto Salvatori,Juliet Jennings,Ángel Ferrández Longás,José Ignacio Labarta Aizpún,Marianthi Georgitsi,Ralf Paschke,Cristina L. Ronchi,Matti Välimäki,Carola Saloranta,Wouter W. de Herder,Renato Cozzi,Mirtha Guitelman,Flavia Magri,Maria Stefania Lagonigro,Georges Halaby,Vinciane Corman,Marie-Thérèse Hagelstein,Jean-Francis Vanbellinghen,Gustavo Barcelos Barra,Anne-Paule Gimenez-Roqueplo,Fergus J. Cameron,Françoise Borson-Chazot,Ian M. Holdaway,Sergio P. A. Toledo,Günter K. Stalla,Anna Spada,Sabina Zacharieva,Jérôme Bertherat,Thierry Brue,Vincent Bours,Philippe Chanson,Lauri A. Aaltonen,Albert Beckers +63 more
TL;DR: Prisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.
Journal ArticleDOI
A Nationwide Survey of Mortality in Acromegaly
Ritva Kauppinen-Mäkelin,Timo Sane,Antti Reunanen,Matti Välimäki,Leo Niskanen,Helene Markkanen,Eliisa Löyttyniemi,Tapani Ebeling,Pia Jaatinen,Hanna Laine,Pirjo Nuutila,Pasi I. Salmela,Jorma Salmi,Ulf-Håkan Stenman,Jorma Viikari,Erkki Voutilainen +15 more
TL;DR: The posttreatment basal GH concentration less than 2.5 microg/liter in acromegalic patients is associated with a normal lifespan, and excess mortality is confined to poorly controlled patients and possibly those who have received conventional radiotherapy.
Journal ArticleDOI
Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia.
Marianthi Georgitsi,Anniina Raitila,Auli Karhu,Rob B. van der Luijt,Cora M. Aalfs,Timo Sane,Outi Vierimaa,Markus J. Mäkinen,Karoliina Tuppurainen,Ralph Paschke,Oliver Gimm,Christian A. Koch,Sadi Gundogdu,Anneke Lucassen,Marc Tischkowitz,Louise Izatt,Simon Aylwin,Gul Bano,Shirley Hodgson,Ernesto De Menis,Virpi Launonen,Pia Vahteristo,Lauri A. Aaltonen +22 more
TL;DR: The results support the previous finding that germline CDKN1B/p27(Kip1) mutations predispose to a human MEN1-like condition.
Journal ArticleDOI
Sex Hormones and Sexual Function in Obese Men Losing Weight
TL;DR: It is concluded that obese men lose weight and increase their serum testosterone level on a weight-loss program with VLED and behavior modification, however, they do not change their sexual function scores.
Journal ArticleDOI
Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.
Marianthi Georgitsi,Anniina Raitila,Auli Karhu,Karoliina Tuppurainen,Markus J. Mäkinen,Outi Vierimaa,Ralf Paschke,Wolfgang Saeger,Rob B. van der Luijt,Timo Sane,Mercedes Robledo,Ernesto De Menis,Robert J. Weil,A. Wasik,Grzegorz Zieliński,Olga Lucewicz,Jan Lubinski,Virpi Launonen,Pia Vahteristo,Lauri A. Aaltonen +19 more
TL;DR: AIP IHC, followed by genetic counseling and possible AIP mutation analysis in IHC-negative cases, appears feasible in identification of PAP, a procedure similar to the diagnostics of the Lynch syndrome.