C
Carrie A. Cowardin
Researcher at University of Virginia
Publications - 17
Citations - 957
Carrie A. Cowardin is an academic researcher from University of Virginia. The author has contributed to research in topics: Clostridium difficile & Immune system. The author has an hindex of 12, co-authored 14 publications receiving 669 citations. Previous affiliations of Carrie A. Cowardin include Washington University in St. Louis & University of Virginia Health System.
Papers
More filters
Journal ArticleDOI
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Jeanette L. Gehrig,Siddarth Venkatesh,Hao Wei Chang,Matthew C. Hibberd,Vanderlene L. Kung,Jiye Cheng,Robert Y. Chen,Sathish Subramanian,Carrie A. Cowardin,Martin Meier,David O'Donnell,Michael Talcott,Larry D. Spears,Clay F. Semenkovich,Bernard Henrissat,Bernard Henrissat,Richard J. Giannone,Robert L. Hettich,Olga Ilkayeva,Michael J. Muehlbauer,Christopher B. Newgard,Christopher S. Sawyer,Richard D. Head,Dmitry A. Rodionov,Dmitry A. Rodionov,Aleksandr A. Arzamasov,Aleksandr A. Arzamasov,Semen A. Leyn,Semen A. Leyn,Andrei L. Osterman,Iqbal Hossain,M Munirul Islam,Nuzhat Choudhury,Shafiqul Alam Sarker,Sayeeda Huq,Imteaz Mahmud,Ishita Mostafa,Mustafa Mahfuz,Michael J. Barratt,Tahmeed Ahmed,Jeffrey I. Gordon +40 more
TL;DR: Identifying ingredients in complementary foods, consumed during the transition from exclusive milk feeding to a fully weaned state, that increase the representation and expressed beneficial functions of growth-promoting bacterial taxa in the developing microbiota could provide an effective, affordable, culturally acceptable, and sustainable approach to treatment.
Journal ArticleDOI
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
Carrie A. Cowardin,Erica L. Buonomo,Mahmoud M. Saleh,Madeline G. Wilson,Stacey L. Burgess,Sarah A. Kuehne,Carsten Schwan,Anna Marei Eichhoff,Friedrich Koch-Nolte,Dena Lyras,Klaus Aktories,Nigel P. Minton,William A. Petri +12 more
TL;DR: It is shown that CDT enhances the virulence of two PCR-ribotype 027 strains in mice and a mechanism by which this binary toxin subverts the host immune response is demonstrated.
Journal ArticleDOI
Microbiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection
Erica L. Buonomo,Carrie A. Cowardin,Madeline G. Wilson,Mahmoud M. Saleh,Patcharin Pramoonjago,William A. Petri +5 more
TL;DR: Findings support a mechanism whereby the induction of IL-25-mediated eosinophilia can reduce host mortality during active CDI, and may provide targets for future development of microbial or immune-based therapies.
Journal ArticleDOI
Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis
Stacey L. Burgess,Erica L. Buonomo,Maureen A. Carey,Carrie A. Cowardin,Caitlin Naylor,Zannatun Noor,Marsha Wills-Karp,William A. Petri +7 more
TL;DR: It is demonstrated that intestinal colonization with a specific commensal bacterium can provide protection during amebiasis in a murine model and that the microbiome can mediate protection against an enteric infection via extraintestinal effects on bone marrow-derived dendritic cells.
Journal ArticleDOI
IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
Alyse Frisbee,Mahmoud M. Saleh,Mary K. Young,Jhansi L. Leslie,Morgan Simpson,Mayuresh M. Abhyankar,Carrie A. Cowardin,Jennie Z. Ma,Patcharin Pramoonjago,Stephen D. Turner,Alice P. Liou,Erica L. Buonomo,William A. Petri +12 more
TL;DR: It is demonstrated that IL-33 prevents C. difficile-associated mortality and epithelial disruption independently of bacterial burden or toxin expression, andIL-33 signaling to ILC2s is an important mechanism of defense from C.difficile colitis.