D
Diane L. Negley
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 17
Citations - 1584
Diane L. Negley is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Marburg virus & Ebola virus. The author has an hindex of 13, co-authored 17 publications receiving 1526 citations. Previous affiliations of Diane L. Negley include United States Department of the Army.
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Marburg Virus Vaccines Based upon Alphavirus Replicons Protect Guinea Pigs and Nonhuman Primates
TL;DR: An RNA replicon, based upon Venezuelan equine encephalitis (VEE) virus, was used as a vaccine vector; the VEE structural genes were replaced by genes for MBGV GP, nucleoprotein (NP), VP40, VP35, VP30, or VP24.
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Ebola and Marburg Viruses Replicate in Monocyte-Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation
Catharine M. Bosio,M. Javad Aman,Case C. Grogan,Robert J. Hogan,Gordon Ruthel,Diane L. Negley,Mansour Mohamadzadeh,Sina Bavari,Alan L. Schmaljohn +8 more
TL;DR: It is demonstrated that EBOV and MARV infected and replicated in primary human DCs without inducing cytokine secretion, and DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms.
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Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections
Dana L. Swenson,Kelly L. Warfield,Diane L. Negley,Alan L. Schmaljohn,M. Javad Aman,Sina Bavari +5 more
TL;DR: The data indicate that vaccination with GP was required and sufficient to protect against a homologous filovirus challenge, as heterologous wild-type VLPs or hybrid V lPs that did not contain thehomologous GP failed to protect.
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Virus inactivation by nucleic acid extraction reagents.
TL;DR: The results support the reliance upon either TRIzol LS Reagent or AVL Buffer to render clinical or environmental samples non-infectious, which has implications for the handling and processing of samples under austere field conditions and low level containment.
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Induction of Humoral and CD8+ T Cell Responses Are Required for Protection against Lethal Ebola Virus Infection
Kelly L. Warfield,Gene G. Olinger,Emily M. Deal,Dana L. Swenson,Michael Bailey,Diane L. Negley,Mary Kate Hart,Sina Bavari +7 more
TL;DR: It is found that CD8+, but not CD4+, T cells are absolutely required for eVLP-mediated protection against EBOV infection, and both E BOV-specific humoral and cytotoxic CD8+ T cell responses are critical to mediate protection against filoviruses following eV LP vaccination.