Catherine Willett

TL;DR: It is demonstrated that the zebrafish is a viable whole animal model for screening small molecules that affect blood vessel formation as a primary screen for compounds that affect angiogenesis.

TL;DR: The postulated AOP is expected to serve as the basis for the development of new in vitro tests and the characterization of novel biomarkers of drug-induced cholestasis, including bile accumulation, the induction of oxidative stress and inflammation, and the activation of specific nuclear receptors.

TL;DR: It is demonstrated that scientific confidence in these pathways can be increased though the use of unconventional information (eg, computational identification of potential initiators) and AOPs at all levels of confidence can contribute to specific uses.

TL;DR: The Pathways of Toxicity (PoT) as discussed by the authors is a molecular definition of cellular processes shown to mediate adverse outcomes of toxicants, and it is further recognized that normal physiological pathways exist that maintain homeostasis and these can become PoTs.

TL;DR: There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales and recommendations to help achieve this.