C
Cecilia B. Cavazzoni
Researcher at Federal University of Rio de Janeiro
Publications - 13
Citations - 343
Cecilia B. Cavazzoni is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Germinal center & Antibody. The author has an hindex of 5, co-authored 9 publications receiving 174 citations. Previous affiliations of Cecilia B. Cavazzoni include Rockefeller University.
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Journal ArticleDOI
Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting
Luka Mesin,Ariën Schiepers,Jonatan Ersching,Alexandru Barbulescu,Cecilia B. Cavazzoni,Alessandro Angelini,Takaharu Okada,Tomohiro Kurosaki,Gabriel D. Victora +8 more
TL;DR: It is found that secondary responses are characterized by a clonality bottleneck that restricts the engagement of the large diversity of MBC clones generated by priming, and understanding how to counter this bottleneck may improve the ability to elicit antibodies to non-immunodominant epitopes by vaccination.
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Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection.
Carolina Lucas,Jamil Z. Kitoko,Fabricio M. Ferreira,Vinicius G. Suzart,Michelle Premazzi Papa,Sharton Vinicius Antunes Coelho,Cecilia B. Cavazzoni,Heitor A. Paula-Neto,Priscilla C. Olsen,Akiko Iwasaki,Renata M. Pereira,Pedro M. Pimentel-Coelho,Andre M. Vale,Luciana Barros de Arruda,Marcelo T. Bozza +14 more
TL;DR: A neutralizing antibody response, dependent on CD4+ T cells and IFNγ signaling, is detected during the first week of infection and is associated with reduced viral load in the brain, prevention of rapid disease onset and survival.
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Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice
Cecilia B. Cavazzoni,Benjamin L. Hanson,Manuel Alfredo Podestà,E Béchu,Rachel L. Clement,Hengcheng Zhang,Joe Daccache,Tamara Reyes-Robles,Erik C. Hett,Kalpit Vora,Olugbeminiyi O. Fadeyi,Rob C. Oslund,Daria J. Hazuda,Peter T. Sage +13 more
TL;DR: In this paper , perturbations of Tfh or Tfr cells after SARS-CoV-2 spike protein vaccination in mice were shown to increase the frequency and somatic hypermutation (SHM) of Spike-specific GC B cells and regulate clonal diversity.
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Immunomodulating role of IL-10-producing B cells in Leishmania amazonensis infection.
Luan Firmino-Cruz,Tadeu Diniz Ramos,Alessandra Marcia da Fonseca-Martins,Diogo Maciel-Oliveira,Gabriel Oliveira-Silva,Juliana Elena Silveira Pratti,Cecilia B. Cavazzoni,Suzana Passos Chaves,Daniel Cláudio de Oliveira Gomes,Alexandre Morrot,Leonardo Freire-de-Lima,Andre M. Vale,Celio Geraldo Freire-de-Lima,Debora Decote-Ricardo,Herbert Leonel de Matos Guedes +14 more
TL;DR: It is demonstrated in this study that follicular B cells from draining lymph nodes of infected wild type BALB/c mice are the major source of IL-10 during infection, and data indicate that B cells are related with lesion pathogenesis through the production of antibodies andIL-10.
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One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.
Johanne T. Jacobsen,Luka Mesin,Styliani Markoulaki,Ariën Schiepers,Cecilia B. Cavazzoni,Cecilia B. Cavazzoni,Djenet Bousbaine,Rudolf Jaenisch,Gabriel D. Victora +8 more
TL;DR: A method for rapid generation of B cell receptor (BCR) monoclonal mice expressing prerearranged Igh and Igk chains monoallelically from the Igh locus by CRISPR-Cas9 injection into fertilized oocytes is developed.