C
Céline Brochot
Researcher at Flemish Institute for Technological Research
Publications - 83
Citations - 2233
Céline Brochot is an academic researcher from Flemish Institute for Technological Research. The author has contributed to research in topics: Physiologically based pharmacokinetic modelling & Population. The author has an hindex of 23, co-authored 78 publications receiving 1788 citations.
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Journal ArticleDOI
The Human Early-Life Exposome (HELIX): Project Rationale and Design
Martine Vrijheid,Rémy Slama,Oliver Robinson,Leda Chatzi,Muireann Coen,Peter van den Hazel,Cathrine Thomsen,John Wright,Toby J. Athersuch,Narcis Avellana,Xavier Basagaña,Céline Brochot,Luca Bucchini,Mariona Bustamante,Angel Carracedo,Maribel Casas,Xavier Estivill,Lesley Fairley,Diana van Gent,Juan R. González,Berit Granum,Regina Gražulevičienė,Kristine B. Gutzkow,Jordi Julvez,Hector C. Keun,Manolis Kogevinas,Rosemary R. C. McEachan,Helle Margrete Meltzer,Eduard Sabidó,Per E. Schwarze,Valérie Siroux,Jordi Sunyer,Elizabeth J. Want,Florence Anna Zeman,Mark J. Nieuwenhuijsen +34 more
TL;DR: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood, and will form an important first step toward the life-course exposomes.
Journal ArticleDOI
Human Early Life Exposome (HELIX) study: A European population-based exposome cohort
Léa Maitre,Jeroen de Bont,Maribel Casas,Oliver Robinson,Gunn Marit Aasvang,Lydiane Agier,Sandra Andrušaitytė,Ferran Ballester,Xavier Basagaña,Eva Borràs,Céline Brochot,Mariona Bustamante,Angel Carracedo,Montserrat de Castro,Audrius Dedele,David Donaire-Gonzalez,Xavier Estivill,Jorunn Evandt,Serena Fossati,Lise Giorgis-Allemand,Juan R. González,Berit Granum,Regina Grazuleviciene,Kristine B. Gutzkow,Line Småstuen Haug,Carles Hernandez-Ferrer,Barbara Heude,Jesús Ibarluzea,Jordi Julvez,Marianna Karachaliou,Hector C. Keun,Norun Hjertager Krog,Chung-Ho E Lau,Vasiliki Leventakou,Sarah Lyon-Caen,Cyntia Manzano,Dan Mason,Rosemary R. C. McEachan,Helle Margrete Meltzer,Inga Petraviciene,Joane Quentin,Theano Roumeliotaki,Eduard Sabidó,Pierre-Jean Saulnier,Alexandros P. Siskos,Valérie Siroux,Jordi Sunyer,Ibon Tamayo,Jose Urquiza,Marina Vafeiadi,Diana van Gent,Marta Vives-Usano,Dagmar Waiblinger,Charline Warembourg,Leda Chatzi,Muireann Coen,Peter van den Hazel,Mark J. Nieuwenhuijsen,Rémy Slama,Cathrine Thomsen,John Wright,Martine Vrijheid +61 more
TL;DR: The HELIX study showed substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder.
Journal ArticleDOI
Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children.
Maribel Casas,Xavier Basagaña,Amrit Kaur Sakhi,Line Småstuen Haug,Claire Philippat,Berit Granum,Cyntia B. Manzano-Salgado,Céline Brochot,Florence Anna Zeman,Jeroen de Bont,Sandra Andrusaityte,Leda Chatzi,David Donaire-Gonzalez,Lise Giorgis-Allemand,Juan R. González,Esther Gracia-Lavedan,Regina Grazuleviciene,Mariza Kampouri,Sarah Lyon-Caen,Pau Pañella,Inga Petraviciene,Oliver Robinson,Jose Urquiza,Marina Vafeiadi,Céline Vernet,Dagmar Waiblinger,John Wright,Cathrine Thomsen,Rémy Slama,Martine Vrijheid +29 more
TL;DR: This quantification of the variability of biomarker measurements of many non-persistent chemicals during several time windows shows that for many of these compounds a few dozen samples are required to accurately assess exposure over periods encompassing several trimesters or months.
Journal ArticleDOI
Improvement of HepG2/C3a cell functions in a microfluidic biochip.
Jean-Matthieu Prot,Caroline Aninat,Laurent Griscom,Florence Razan,Céline Brochot,Christiane Guillouzo,Cécile Legallais,Anne Corlu,Eric Leclerc +8 more
TL;DR: Microfluidic biochip could and provide an important insight to exploring the xenobiotic's metabolism as a new pertinent tool for predicting cell toxicity and clearance of xenobiotics in vitro.
Journal ArticleDOI
Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.
Laetitia Shintu,Régis Baudoin,Vincent Navratil,Jean-Matthieu Prot,Clément Pontoizeau,Marianne Defernez,Benjamin J. Blaise,Céline Domange,Alexandre R.R. Pery,Pierre Toulhoat,Cécile Legallais,Céline Brochot,Eric Leclerc,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas +14 more
TL;DR: The integration of microtechnology, cell culture in microfluidic biochips, and metabolic profiling opens the development of so-called "metabolomics-on-a-chip" assays in pharmaceutical and environmental toxicology.