C
Céline Keime
Researcher at University of Strasbourg
Publications - 75
Citations - 3926
Céline Keime is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 26, co-authored 63 publications receiving 3292 citations. Previous affiliations of Céline Keime include Centre national de la recherche scientifique & Commissariat à l'énergie atomique et aux énergies alternatives.
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Journal ArticleDOI
A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis
Marie-Agnès Dillies,Andrea Rau,Julie Aubert,Christelle Hennequet-Antier,Marine Jeanmougin,Nicolas Servant,Céline Keime,Guillemette Marot,David Castel,Jordi Estellé,Gregory Guernec,Bernd Jagla,Luc Jouneau,Denis Laloë,Caroline Le Gall,Brigitte Schaeffer,Stéphane Le Crom,Mickaël Guedj,Florence Jaffrézic +18 more
TL;DR: This work focuses on a comprehensive comparison of seven recently proposed normalization methods for the differential analysis of RNA-seq data, with an emphasis on the use of varied real and simulated datasets involving different species and experimental designs to represent data characteristics commonly observed in practice.
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seqMINER: an integrated ChIP-seq data interpretation platform
Tao Ye,Arnaud R Krebs,Mohamed Amin Choukrallah,Céline Keime,Frédéric Plewniak,Irwin Davidson,Laszlo Tora +6 more
TL;DR: An integrated portable ChIP-seq data interpretation platform called seqMINER, with optimized performances for efficient handling of multiple genome-wide datasets, which can handle the biological complexity of most experimental situations and proposes methods to the user for data classification according to the analysed features.
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Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Thomas Strub,Sandy Giuliano,Tao Ye,Caroline Bonet,Céline Keime,D Kobi,S Le Gras,Mireille Cormont,Robert Ballotti,Corine Bertolotto,Irwin Davidson +10 more
TL;DR: The identification of MITF-binding sites and gene-regulatory networks establish a framework for understanding oncogenic basic helix-loop-helix factors such as N-myc or TFE3 in other cancers.
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Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells
Maud de Dieuleveult,Kuangyu Yen,Kuangyu Yen,Isabelle Hmitou,Arnaud Depaux,Fayçal Boussouar,Daria Bou Dargham,Sylvie Jounier,Hélène Humbertclaude,Florence Ribierre,Céline Baulard,Nina Farrell,Bongsoo Park,Céline Keime,Lucie Carrière,Soizick Berlivet,Marta Gut,Ivo Gut,Michel Werner,Jean-François Deleuze,Robert Olaso,Jean-Christophe Aude,Sophie Chantalat,B. Franklin Pugh,Matthieu Gérard +24 more
TL;DR: Findings indicate that remodellers target specific nucleosomes at the edge of NFRs, where they regulate ES cell transcriptional programs.
Journal ArticleDOI
Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells
Patrick Laurette,Thomas Strub,Dana Koludrovic,Céline Keime,Stéphanie Le Gras,Hannah Seberg,Eric Van Otterloo,Hana Imrichova,Robert Siddaway,Stein Aerts,Robert A. Cornell,Gabrielle Mengus,Irwin Davidson +12 more
TL;DR: A comprehensive MITF interactome is defined identifying novel cofactors involved in transcription, DNA replication and repair, and chromatin organisation and it is shown that MITF interacts with a PBAF chromatin remodelling complex comprising BRG1 and CHD7.