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Chang-Lun Shao
Researcher at Ocean University of China
Publications - 233
Citations - 5271
Chang-Lun Shao is an academic researcher from Ocean University of China. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 34, co-authored 217 publications receiving 3976 citations. Previous affiliations of Chang-Lun Shao include Chinese Ministry of Education & Sun Yat-sen University.
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Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, and antibacterial activities of p-terphenyl derivatives.
Xue-Qing Zhang,Xiao-Feng Mou,Ning Mao,Jiejie Hao,Ming Liu,Ji-Yong Zheng,Chang-Yun Wang,Yu-Cheng Gu,Chang-Lun Shao +8 more
TL;DR: Terphenyllin (1), a naturally abundant p-terphenyl metabolite, was isolated from the coral derived fungus Aspergillus candidus together with four natural analogues 2-5 to evaluate their potency and selectivity and found to exhibit strong cytotoxicity against three tumor cell lines.
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Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms
TL;DR: It could be concluded that co-culture can be an effective strategy to tap the metabolic potential of microorganisms, particularly for marine-derived species, thus providing diverse molecules for the discovery of lead compounds and drug candidates.
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Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group.
Chang-Lun Shao,Chang-Lun Shao,Xiao-Feng Mou,Fei Cao,Carmenza Spadafora,Evgenia Glukhov,Lena Gerwick,Chang-Yun Wang,William H. Gerwick +8 more
TL;DR: A methanolysis mechanism for bastimolide A is proposed, and one unexpected isomerization product of the C2-C3 double bond, 2-(E)-bastimolides A (3), was obtained.
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Phylogenetic Diversity and Antibacterial Activity of Culturable Fungi Derived from the Zoanthid Palythoa haddoni in the South China Sea
TL;DR: More than 60 % of the active fungal strains showed strong activity against two aquatic pathogenic bacteria Nocardia brasiliensis and Vibrio parahaemolyticus, indicating that zoanthid-derived fungi may protect its host against pathogens.
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Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L -Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
Wei-Feng Xu,Wei-Feng Xu,Xue-Mei Hou,Fei-Hua Yao,Na Zheng,Jun Li,Chang-Yun Wang,Rui-Yun Yang,Chang-Lun Shao +8 more
TL;DR: Two new cyclopentapeptides, xylapeptide A (1) with an uncommon L-pipecolinic acid moiety, and xylAPEptide B (2) having a common L-proline residue were identified from an associated fungus Xylaria sp.