https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

The indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. This review covers some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis.

Biomedical Importance of Indoles

Secondary metabolites of fungi from marine habitats.

Cadmium is a heavy metal of considerable toxicity with destructive impact on most organ systems. It is widely distributed in humans, the chief sources of contamination being cigarette smoke, welding, and contaminated food and beverages. Toxic impacts are discussed and appear to be proportional to body burden of cadmium. Detoxification of cadmium with EDTA and other chelators is possible and has been shown to be therapeutically beneficial in humans and animals when done using established protocols.

/pdf/cadmium-toxicity-and-treatment-5fbskqefiu.pdf

Cadmium Toxicity and Treatment

Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

Review: Marine natural products

Two new steroidal glycosides, fragilioside A (1) and fragilioside B (2), along with five known compounds (3–7) were isolated from the gorgonian Dichotella fragilis (Ridleg) collected from the South...

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1100600907

Chemical constituents of the Gorgonian Dichotella fragilis (Ridleg) from the South China Sea.

Vibrational circular dichroism (VCD) method has become robust and reliable alternative for the stereochemical characterization of natural products. In this paper, three new serrulatane-type diterpenoids, euplexaurenes A–C (1–3), and a known metabolite, anthogorgiene P (4), were obtained from the South China Sea gorgonian Euplexaura sp. GXWZ-05. The absolute configuration of C-11 in 1–4, which was difficult to be determined by common means due to the high conformational flexibility of the eight-carbon aliphatic chain attached at C-4, was determined by VCD method, suggesting a new horizon to define the absolute configurations of natural products possessing chains. Compounds 1–4 were found to show selective cytotoxic activities against human laryngeal carcinoma (Hep-2) cell line with the IC50 values of 1.95, 7.80, 13.6 and 5.85 μM, respectively.

/pdf/cytotoxic-serrulatane-type-diterpenoids-from-the-gorgonian-2sit9sbd25.pdf

Cytotoxic Serrulatane-Type Diterpenoids from the Gorgonian Euplexaura sp. and Their Absolute Configurations by Vibrational Circular Dichroism.

Scopuquinolone B, a new monoterpenoid dihydroquinolin-2(1H)-one isolated from the coral-derived Scopulariopsis sp. fungus

Marine-derived microorganisms have proved to be a rich and important source of drugs. A huge number of secondary metabolites from marine-derived microorganisms have become significant chemical entities in drug discovery. Marine macrolides, a highly oxygenated and stereochemically elaborated group of secondary metabolites, have been attracting increasing interest. New macrolides with multiple potent biological activities have been isolated from diverse marine microorganisms in recent years. We reviewed marine macrolides from marine fungi and bacteria including actinomycetes and cyanobacteria reported between 2002 and 2013 with an emphasis on their structures, biological activities, and synthesis.

The Chemistry and Bioactivity of Macrolides from Marine Microorganisms

0009-3130/12/4801-0158 2012 Springer Science+Business Media, Inc. 1) Key Laboratory of Marine Drugs, Ministry of Education, the School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China, e-mail: changyun@ouc.edu.cn; 2) College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, P. R. China. Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 142–143, January–February, 2012. Original article submitted August 31, 2010. Chemistry of Natural Compounds, Vol. 48, No. 1, March, 2012 [Russian original No. 1, January–February, 2012]

Chang-Lun Shao

Papers

Chemical constituents of the Gorgonian Dichotella fragilis (Ridleg) from the South China Sea.

Cytotoxic Serrulatane-Type Diterpenoids from the Gorgonian Euplexaura sp. and Their Absolute Configurations by Vibrational Circular Dichroism.

Scopuquinolone B, a new monoterpenoid dihydroquinolin-2(1H)-one isolated from the coral-derived Scopulariopsis sp. fungus

The Chemistry and Bioactivity of Macrolides from Marine Microorganisms

Steroids and triterpenoids from the brown alga Kjellmaniella crassifolia