C
Chang Sheng Chang
Researcher at Georgia Regents University
Publications - 15
Citations - 422
Chang Sheng Chang is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Stem cell & breakpoint cluster region. The author has an hindex of 7, co-authored 11 publications receiving 282 citations.
Papers
More filters
Journal ArticleDOI
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
Rajneesh Pathania,Sabarish Ramachandran,Selvakumar Elangovan,Ravi Padia,Pengyi Yang,Senthilkumar Cinghu,Rajalakshmi Veeranan-Karmegam,Pachiappan Arjunan,Jaya P. Gnana-Prakasam,Fulzele Sadanand,Lirong Pei,Chang Sheng Chang,Jeong Hyeon Choi,Huidong Shi,Santhakumar Manicassamy,Puttur D. Prasad,Suash Sharma,Vadivel Ganapathy,Raja Jothi,Muthusamy Thangaraju +19 more
TL;DR: An essential role for DNMT1 is uncovered in MaSC and CSC maintenance and theDNMT1-ISL1 axis is identified as a potential therapeutic target for breast cancer treatment.
Journal ArticleDOI
CD73 on cancer-associated fibroblasts enhanced by the A 2B -mediated feedforward circuit enforces an immune checkpoint
Miao Yu,Gang Guo,Lei Huang,Libin Deng,Chang Sheng Chang,Bhagelu R. Achyut,Madison Canning,Ningchun Xu,Ali S. Arbab,Roni J. Bollag,Paulo C. Rodriguez,Andrew L. Mellor,Huidong Shi,David H. Munn,Yan Cui +14 more
TL;DR: It is demonstrated that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Cell suppression and tumour growth.
Journal ArticleDOI
Genomic analysis of racial differences in triple negative breast cancer
TL;DR: Genes with high frequency mutation rates such as MUC4 and TP53 were common to both racial populations, however genes that were less frequently mutated differed between the races suggesting that those cause the more aggressive nature of TNBC in AA women.
Journal ArticleDOI
miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes.
Tianxiang Hu,Yating Chong,Sumin Lu,Rebecca Wang,Haiyan Qin,Jeane Silva,Eiko Kitamura,Chang Sheng Chang,Lesleyann Hawthorn,John K. Cowell +9 more
TL;DR: Proapoptiotic genes that are direct targets of miR-339-5p significantly influence promotion and aggressive development of leukemia/lymphomas associated with FGFR1 overexpression.
Journal ArticleDOI
The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase
Tianxiang Hu,Yating Chong,Haiyan Qin,Eiko Kitamura,Chang Sheng Chang,Jeane Silva,Mingqiang Ren,John K. Cowell,John K. Cowell +8 more
TL;DR: Overall, miR-17/92 is defined as a downstream effector of FGFR1 in BCR-FGFR1-driven B-cell lymphoblastic leukemia.