Changlu Xu

TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.

TL;DR: This work provides a transcriptional map of human blood cells at single-cell resolution, thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis.

TL;DR: In this article, single-cell RNA and T cell receptor sequencing was used to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease (aGVHD) who undergo stem cell transplantation.

TL;DR: It is discovered that while EMT occurs at the onset of human hematopoietic differentiation, MET is not detected subsequently during differentiation, and biphasic regulation of mesenchymal genes is an essential mechanism during human heMatopoiesis.

TL;DR: In this article, a specific deficiency of PTBP1 in Dendritic cells was found to increase MHC II expression and perturb T cell homeostasis without affecting DC development.