Hongtao Wang

TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.

TL;DR: It is discovered that UCA1 expression is dynamically regulated during human erythroid maturation, with a maximal expression in proerythroblasts, and a lncRNA-mediated posttranscriptional mechanism that provides a new dimension into how the fundamental heme biosynthesis process is regulated as a determinant of erythrocyte development is defined.

TL;DR: Muscle segment homeobox 2 (MSX2), a homeOBox transcription factor of msh family, is reported as a direct target gene of BMP signaling and a master mediator of hPSCs' differentiation to mesendoderm.

TL;DR: A critical role of muscle segment homeobox 2 (MSX2) is identified in initiating and accelerating the molecular program that leads to mesenchymal stem/stromal cell (MSC) differentiation from hPSCs.

TL;DR: Myeloid ectopic viral integration site 1 homolog (MEIS1) is identified as a crucial regulator of hPSC early hematopoietic differentiation and can be potentially manipulated for large-scale generation of HPCs or platelets from hPSCs for therapeutic applications in regenerative medicine.