Pei Su

TL;DR: An essential role for the serine/threonine protein kinase mammalian target of rapamycin (mTOR) in regulating hESC long-term undifferentiated growth is demonstrated and a novel signaling mechanism by which mTOR controls fate decisions in hESCs is uncovered.

TL;DR: These findings provide a single‐step cost‐effective method for efficient derivation of neural progenitor cells in adherent culture from human pluripotent stem cells and should facilitate the use of stem cells in drug screening and regenerative medicine and study of early human neural development.

TL;DR: Nonmuscle myosin IIA and p120-catenin control E-cadherin–mediated cell–cell adhesions essential for hESC pluripotency and long-term survival.

TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.

TL;DR: In this article, a lead chemical compound, (E)-4-(2-(4-chloro-3-nitrophenyl) (named as C87), was identified, which directly binds to TNFα, and potently inhibits TNF-induced cytotoxicity (IC50 = 8.73 μm).