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Changwei Liu
Researcher at Beckman Research Institute
Publications - 12
Citations - 765
Changwei Liu is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: DNA repair & Control of chromosome duplication. The author has an hindex of 7, co-authored 12 publications receiving 630 citations. Previous affiliations of Changwei Liu include City of Hope National Medical Center & Zhejiang University.
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Journal ArticleDOI
Reciprocal Regulation of Akt and Oct4 Promotes the Self-Renewal and Survival of Embryonal Carcinoma Cells
Yuanji Lin,Ying Yang,Weihua Li,Qi Chen,Jie Li,Xiao Pan,Lina Zhou,Changwei Liu,Changwei Liu,Chunsong Chen,Jianqin He,Hongcui Cao,Hangping Yao,Li Zheng,Xiaowei Xu,Zongping Xia,Jiangtao Ren,Lei Xiao,Lanjuan Li,Binghui Shen,Binghui Shen,Honglin Zhou,Ying-Jie Wang +22 more
TL;DR: A site-specific, posttranslational modification of the Oct4 protein orchestrates the regulation of its stability, subcellular localization, and transcriptional activities, which collectively promotes the survival and tumorigenicity of ECCs.
Journal ArticleDOI
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
Weiqiang Lin,Shilpa Sampathi,Huifang Dai,Changwei Liu,Changwei Liu,Mian Zhou,Jenny Hu,Qing Huang,Judith L. Campbell,Kazuo Shin-ya,Li Zheng,Weihang Chai,Binghui Shen +12 more
TL;DR: The genetic, cytological, and biochemical results suggest that mammalian DNA2 reduces replication stress at telomeres, thereby preserving genome stability and suppressing cancer development, and that this may involve, at least in part, nucleolytic processing of telomeric G4.
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Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability.
Dario Ronchi,Alessio Di Fonzo,Weiqiang Lin,Andreina Bordoni,Changwei Liu,Elisa Fassone,Serena Pagliarani,Mafalda Rizzuti,Li Zheng,Massimiliano Filosto,Maria Teresa Ferrò,Michela Ranieri,Francesca Magri,Lorenzo Peverelli,Hongzhi Li,Yate Ching Yuan,Stefania Corti,Monica Sciacco,Maurizio Moggio,Nereo Bresolin,Binghui Shen,Giacomo P. Comi +21 more
TL;DR: DNA2 encodes a helicase/nuclease family member that is most likely involved in mtDNA replication, as well as in the long-patch base-excision repair (LP-BER) pathway, which implicate human DNA2 and the LP-BER pathway in the pathogenesis of adult-onset disorders of mtDNA maintenance.
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Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression
Zhigang Guo,Julie Kanjanapangka,Na Liu,Songbai Liu,Songbai Liu,Changwei Liu,Changwei Liu,Zhenxing Wu,Zhenxing Wu,Ying-Jie Wang,Tiffany Loh,Claudia M. Kowolik,Joonas Jamsen,Mian Zhou,Khue Truong,Yuan Chen,Li Zheng,Binghui Shen,Binghui Shen +18 more
TL;DR: It is found that FEN1 phosphorylation stimulated its SUMOylation, which in turn stimulated its ubiquitination, which led to its degradation via the proteasome pathway, which may represent a newly identified regulatory mechanism used by cells to ensure precise cell-cycle progression and to prevent transformation.
Journal ArticleDOI
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
Li Zheng,Huifang Dai,Mian Zhou,Xiaojin Li,Changwei Liu,Changwei Liu,Zhigang Guo,Zhigang Guo,Xiwei Wu,Jun Wei Wu,Charles Wang,John D. Zhong,Qin Huang,Julio Garcia-Aguilar,Gerd P. Pfeifer,Binghui Shen,Binghui Shen +16 more
TL;DR: Formation of polyploidy, which is often observed in human cancers, leads to overexpression of BRCA1, p19arf and other DNA repair genes in FEN1 mutant cells, which triggers SSB repair and non-homologous end joining pathways to increase DNA repair activity, but at the cost of frequent chromosomal translocations.