Y
Yushan Li
Researcher at Cornell University
Publications - 18
Citations - 5378
Yushan Li is an academic researcher from Cornell University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 11, co-authored 16 publications receiving 4912 citations. Previous affiliations of Yushan Li include Yeshiva University.
Papers
More filters
Journal ArticleDOI
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Maria E. Figueroa,Omar Abdel-Wahab,Chao Lu,Patrick S. Ward,Jay P. Patel,Alan Shih,Yushan Li,Neha Bhagwat,Aparna Vasanthakumar,Hugo F. Fernandez,Martin S. Tallman,Zhuoxin Sun,Kristy L. Wolniak,Justine K. Peeters,Wei Liu,Sung E. Choe,Valeria Fantin,Elisabeth Paietta,Bob Löwenberg,Jonathan D. Licht,Lucy A. Godley,Ruud Delwel,Peter J. M. Valk,Craig B. Thompson,Ross L. Levine,Ari Melnick +25 more
TL;DR: Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specificHypermethylation signature, suggesting a shared proleukemogenic effect.
Journal ArticleDOI
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Jose M. Polo,Susanna Liu,Maria E. Figueroa,Warakorn Kulalert,Sarah Eminli,Kah Yong Tan,Effie Apostolou,Matthias Stadtfeld,Yushan Li,Toshihiro Shioda,Sridaran Natesan,Amy J. Wagers,Ari Melnick,Todd Evans,Konrad Hochedlinger +14 more
TL;DR: It is shown that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns, and it is demonstrated that cellular origin influences the in vitro differentiation potentials of iPSC into embryoid bodies and different hematopsic cell types.
Journal ArticleDOI
DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia
Maria E. Figueroa,Sanne Lugthart,Yushan Li,Claudia A.J. Erpelinck-Verschueren,Xutao Deng,Paul J. Christos,Elizabeth D. Schifano,James G. Booth,Wim H. van der Putten,Lucy Skrabanek,Fabien Campagne,Madhu Mazumdar,John M. Greally,Peter J. M. Valk,Bob Löwenberg,Ruud Delwel,Ari Melnick +16 more
TL;DR: DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profile.
Journal ArticleDOI
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
Maria E. Figueroa,Lucy Skrabanek,Yushan Li,Anchalee Jiemjit,Tamer E. Fandy,Elisabeth Paietta,Hugo Fernandez,Martin S. Tallman,John M. Greally,Hetty E. Carraway,Jonathan D. Licht,Steven D. Gore,Ari Melnick +12 more
TL;DR: Aberrant methylation in MDS and secondary AML tended to affect particular chromosomal regions, occurred more frequently in Alu-poor genes, and included prominent involvement of genes involved in the WNT and MAPK signaling pathways.
Journal ArticleDOI
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
Raajit K. Rampal,Altuna Alkalin,Altuna Alkalin,Jozef Madzo,Aparna Vasanthakumar,Elodie Pronier,Jay P. Patel,Yushan Li,Jihae Ahn,Omar Abdel-Wahab,Alan Shih,Chao Lu,Patrick S. Ward,Jennifer Tsai,Todd Hricik,Valeria Tosello,Jacob Tallman,Xinyang Zhao,Danette L. Daniels,Qing Dai,Luisa Ciminio,Iannis Aifantis,Chuan He,François Fuks,Martin S. Tallman,Adolfo A. Ferrando,Stephen D. Nimer,Elisabeth Paietta,Craig B. Thompson,Jonathan D. Licht,Christopher E. Mason,Lucy A. Godley,Ari Melnick,Maria E. Figueroa,Maria E. Figueroa,Ross L. Levine +35 more
TL;DR: Data provide a role for WT1 in regulating DNA hydroxymethylation and suggest that TET2 IDH1/IDH2 and WT1 mutations define an AML subtype defined by dysregulated DNA hydroxymethylation.