S
Stephanie Humblet-Baron
Researcher at Katholieke Universiteit Leuven
Publications - 110
Citations - 2418
Stephanie Humblet-Baron is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 22, co-authored 85 publications receiving 1652 citations. Previous affiliations of Stephanie Humblet-Baron include Allen Institute for Brain Science & University of Washington.
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Journal ArticleDOI
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3 + regulatory T cells
Wim Pierson,Bénédicte Cauwe,Antonia N. Policheni,Antonia N. Policheni,Susan M. Schlenner,Dean Franckaert,Julien Berges,Julien Berges,Stephanie Humblet-Baron,Susann Schönefeldt,Marco J Herold,Marco J Herold,David A. Hildeman,David A. Hildeman,Andreas Strasser,Andreas Strasser,Philippe Bouillet,Philippe Bouillet,Li-Fan Lu,Patrick Matthys,Antonio A. Freitas,Antonio A. Freitas,Rita J. Luther,Casey T. Weaver,James Dooley,Daniel H.D. Gray,Daniel H.D. Gray,Adrian Liston +27 more
TL;DR: It is reported that peripheral Treg cells markedly alter their proliferative and apoptotic rates to rapidly restore numerical deficit through an interleukin 2–dependent and costimulation-dependent process.
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Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
Stephanie Humblet-Baron,Blythe D. Sather,Stephanie Anover,Shirly Becker-Herman,Debora J. Kasprowicz,Socheath Khim,Thuc Nghi Nguyen,Kelly Hudkins-Loya,Charles E. Alpers,Steve F. Ziegler,Hans D. Ochs,Troy R. Torgerson,Daniel J. Campbell,David J. Rawlings +13 more
TL;DR: Wiskott-Aldrich syndrome protein (WASp) Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spontaneous revertant mutation, indicating that altered Treg fitness likely explains the autoimmune features in human WAS.
Journal ArticleDOI
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Lore Vanderbeke,P. Van Mol,Y. Van Herck,F. De Smet,Stephanie Humblet-Baron,Kimberly Martinod,Asier Antoranz,Ingrid Arijs,Bram Boeckx,Francesca Maria Bosisio,M. Casaer,Dieter Dauwe,W. De Wever,Christophe Dooms,Erwin Dreesen,A. Emmaneel,J. Filtjens,M. Gouwy,Jan Gunst,Greet Hermans,Steven Jansen,Katrien Lagrou,Adrian Liston,N. Lorent,Philippe Meersseman,Toine Mercier,Johan Neyts,J. Odent,Dena Panovska,P. A. Penttila,E. Pollet,Paul Proost,Junbin Qian,K. Quintelier,Jeroen Raes,S. Rex,Yvan Saeys,Jenny Sprooten,Sabine Tejpar,Dries Testelmans,Karin Thevissen,T. Van Buyten,J. Vandenhaute,S. Van Gassen,L. C. Velásquez Pereira,R. Vos,Birgit Weynand,A. Wilmer,Jonas Yserbyt,Abhishek D. Garg,Patrick Matthys,Carine Wouters,D Lambrechts,Els Wauters,Joost Wauters +54 more
TL;DR: A myeloid-driven immunopathology is suggested, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity.
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Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency
Lien Van Eyck,Lien De Somer,Diana Pombal,Simon Bornschein,Glynis Frans,Stephanie Humblet-Baron,Leen Moens,Francis de Zegher,Xavier Bossuyt,Carine Wouters,Adrian Liston +10 more
TL;DR: To identify the underlying genetic defect in a 16‐year‐old girl with severe early‐onset and refractory systemic lupus erythematosus (SLE), IgA deficiency, and mild lower limb spasticity without neuroradiologic manifestations.
Journal ArticleDOI
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer
Phyllis W. Yu,Ruby S. Tabuchi,Roberta M. Kato,Alexander Astrakhan,Stephanie Humblet-Baron,Kevin R. Kipp,Keun Chae,Wilfried Ellmeier,Owen N. Witte,David J. Rawlings +9 more
TL;DR: It is demonstrated that gene transfer into hematopoietic stem cells can reconstitute Btk-dependent B-cell development and function in vivo, and strongly support the feasibility of pursuing Btk gene transfer for XLA.