Charles G. Danko

TL;DR: Analysis of comprehensive mapping of transcription start sites in human lymphoblastoid B cell and chronic myelogenous leukemic ENCODE Tier 1 cell lines identifies a common architecture of initiation, including tightly spaced (110 bp apart) divergent initiation, similar frequencies of core promoter sequence elements, highly positioned flanking nucleosomes and two modes of transcription factor binding.

TL;DR: This work used a Bayesian, coalescent-based approach to obtain information about ancestral population sizes, divergence times and migration rates from inferred genealogies at many neutrally evolving loci across the genome.

TL;DR: The immediate effects of estrogen signaling on the transcriptome of breast cancer cells using global run-on and sequencing (GRO-seq) are reported and a large number of previously undetected estrogen-regulated intergenic transcripts are identified.

TL;DR: The extent of whole-genome and exome diversity among the five men, reporting 1.3 million novel DNA differences genome-wide, including 13,146 novel amino acid variants, suggests the Bushmen seem to be more different from each other than, for example, a European and an Asian.

TL;DR: New light is shed on the activity of ESR1 at its enhancer sites and an enhancer transcription "signature" based on GRO-seq data can be used for de novo enhancer prediction across cell types.