Fangqing Zhao

TL;DR: A novel causal role of aberrant gut microbiota in contributing to the pathogenesis of hypertension is described and the significance of early intervention for pre-hypertension was emphasized.

TL;DR: A novel chiastic clipping signal-based algorithm, CIRI, is presented, to unbiasedly and accurately detect circRNAs from transcriptome data by employing multiple filtration strategies and to identify and experimentally validate the prevalence of intronic/intergenic circ RNAs as well as fragments specific to them in the human transcriptome.

TL;DR: It is found that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals, and single-nucleotide polymorphism-based analysis indicates that antibiotic resistant genes from the two European populations are more closely related while the Chinese ones are clustered separately.

TL;DR: The extent of whole-genome and exome diversity among the five men, reporting 1.3 million novel DNA differences genome-wide, including 13,146 novel amino acid variants, suggests the Bushmen seem to be more different from each other than, for example, a European and an Asian.

TL;DR: An improved multithreading detection tool, CIRI2, which used an adapted maximum likelihood estimation based on multiple seed matching to identify back‐spliced junction reads and to filter false positives derived from repetitive sequences and mapping errors is proposed.