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Charles J. Lowenstein
Researcher at University of Rochester Medical Center
Publications - 190
Citations - 28984
Charles J. Lowenstein is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 68, co-authored 181 publications receiving 27741 citations. Previous affiliations of Charles J. Lowenstein include University of Texas Southwestern Medical Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
Tsung Cheng Chang,Erik A. Wentzel,Oliver A. Kent,Kalyani Ramachandran,Michael Mullendore,Kwang Hyuck Lee,Georg Feldmann,Munekazu Yamakuchi,Marcella Ferlito,Charles J. Lowenstein,Dan E. Arking,Michael A. Beer,Anirban Maitra,Joshua T. Mendell +13 more
TL;DR: It is demonstrated that microRNAs (miRNAs) are important components of the p53 transcriptional network and miR-34a-responsive genes are highly enriched for those that regulate cell-cycle progression, apoptosis, DNA repair, and angiogenesis.
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Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
JoAnne L. Flynn,Marsha M. Goldstein,John Chan,Karla J. Triebold,Klaus Pfeffer,Charles J. Lowenstein,Robert Schrelber,Tak W. Mak,Barry R. Bloom +8 more
TL;DR: The data from both models established that TNF alpha and the 55 kDa TNF receptor are essential for protection against tuberculosis in mice, and for reactive nitrogen production by macrophages early in infection.
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The Central Role of CD4+ T Cells in the Antitumor Immune Response
Kenneth Hung,Robert J. Hayashi,Anne Lafond-Walker,Charles J. Lowenstein,Drew M. Pardoll,Hyam I. Levitsky +5 more
TL;DR: Analysis of the effector phase of tumor rejection induced by vaccination with irradiated tumor cells transduced to secrete granulocyte/macrophage colony-stimulating factor indicates a far broader role for CD4+ T cells in orchestrating the host response to tumor.
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miR-34a repression of SIRT1 regulates apoptosis
TL;DR: It is shown that the microRNA miR-34a regulates silent information regulator 1 (SIRT1) expression, which functions as a tumor suppressor, in part, through a SIRT1-p53 pathway.