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Chek Meng Poh
Researcher at Agency for Science, Technology and Research
Publications - 25
Citations - 4443
Chek Meng Poh is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Epitope & Cytotoxic T cell. The author has an hindex of 12, co-authored 23 publications receiving 2908 citations. Previous affiliations of Chek Meng Poh include National University of Singapore & Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
The trinity of COVID-19: immunity, inflammation and intervention.
Matthew Zirui Tay,Chek Meng Poh,Laurent Rénia,Laurent Rénia,Paul A. MacAry,Lisa F. P. Ng,Lisa F. P. Ng,Lisa F. P. Ng +7 more
TL;DR: The interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression is described and the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation are highlighted.
Journal ArticleDOI
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients.
Chek Meng Poh,Guillaume Carissimo,Bei Wang,Siti Naqiah Amrun,Cheryl Yi-Pin Lee,Rhonda Sin-Ling Chee,Siew-Wai Fong,Siew-Wai Fong,Nicholas Kim-Wah Yeo,Wen Hsin Lee,Anthony Torres-Ruesta,Anthony Torres-Ruesta,Yee Sin Leo,Mark I-Cheng Chen,Seow Yen Tan,Louis Yi Ann Chai,Louis Yi Ann Chai,Shirin Kalimuddin,Shirin Kalimuddin,Shirley Seah Gek Kheng,Siew Yee Thien,Barnaby Edward Young,Barnaby Edward Young,David C. Lye,Brendon J. Hanson,Cheng-I Wang,Laurent Rénia,Lisa F. P. Ng,Lisa F. P. Ng,Lisa F. P. Ng +29 more
TL;DR: Using pools of overlapping linear B-cell peptides, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development.
Journal ArticleDOI
PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria
Joshua M. Horne-Debets,Rebecca J. Faleiro,Deshapriya S. Karunarathne,Xueqin Liu,Xueqin Liu,Katie E. Lineburg,Chek Meng Poh,Chek Meng Poh,Gijsbert M. Grotenbreg,Geoffrey R. Hill,Kelli P. A. MacDonald,Michael F. Good,Michael F. Good,Laurent Rénia,Laurent Rénia,Rafi Ahmed,Arlene H. Sharpe,Michelle N. Wykes +17 more
TL;DR: It is shown that PD-1 mediates up to a 95% reduction in numbers and functional capacity of parasite-specific CD8(+) T cells, which provides a molecular explanation for chronic malaria that will be relevant to future malaria-vaccine design and may need consideration when vaccine development for other infections is problematic.
Journal ArticleDOI
Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria
Shanshan W. Howland,Chek Meng Poh,Chek Meng Poh,Sin Yee Gun,Sin Yee Gun,Carla Claser,Benoit Malleret,Nilabh Shastri,Florent Ginhoux,Gijsbert M. Grotenbreg,Laurent Rénia,Laurent Rénia +11 more
TL;DR: It is demonstrated here that PbA infection causes brain microvessels to cross‐present parasite antigen, while non‐ECM‐causing parasites do not, and combined therapies targeting both the parasite and host antigen‐presenting cells may improve the outcome of CM patients.
Journal ArticleDOI
Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity.
Siti Naqiah Amrun,Cheryl Yi-Pin Lee,Bernett Lee,Siew-Wai Fong,Siew-Wai Fong,Barnaby Edward Young,Barnaby Edward Young,Rhonda Sin-Ling Chee,Nicholas Kim-Wah Yeo,Anthony Torres-Ruesta,Anthony Torres-Ruesta,Guillaume Carissimo,Chek Meng Poh,Zi Wei Chang,Matthew Zirui Tay,Yi Hao Chan,Mark I-Cheng Chen,Jenny G. Low,Jenny G. Low,Paul A. Tambyah,Shirin Kalimuddin,Shirin Kalimuddin,Surinder Pada,Seow Yen Tan,Louisa Jin Sun,Yee Sin Leo,David C. Lye,Laurent Rénia,Lisa F. P. Ng +28 more
TL;DR: IgG responses to the peptide epitopes can serve as useful indicators for the degree of immunopathology in COVID-19 patients, and function as higly specific and sensitive sero-immunosurveillance tools for recent or past SARS-CoV-2 infections.