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Benoit Malleret
Researcher at National University of Singapore
Publications - 94
Citations - 8163
Benoit Malleret is an academic researcher from National University of Singapore. The author has contributed to research in topics: Plasmodium vivax & Plasmodium falciparum. The author has an hindex of 33, co-authored 85 publications receiving 6284 citations. Previous affiliations of Benoit Malleret include University of Paris-Sud & Singapore Immunology Network.
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Journal ArticleDOI
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
Andreas Schlitzer,Naomi McGovern,Pearline Teo,Teresa Zelante,Koji Atarashi,Donovan Low,Adrian W. S. Ho,Peter See,Amanda Shin,Pavandip Singh Wasan,Guillaume Hoeffel,Benoit Malleret,Alexander F. Heiseke,Samantha Chew,Laura Jardine,Harriet A. Purvis,Catharien M. U. Hilkens,John Kit Chung Tam,Michael Poidinger,E. Richard Stanley,Anne Krug,Laurent Rénia,Baalasubramanian Sivasankar,Lai Guan Ng,Matthew Collin,Paola Ricciardi-Castagnoli,Kenya Honda,Muzlifah Haniffa,Florent Ginhoux +28 more
TL;DR: The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies.
Journal ArticleDOI
Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
Muzlifah Haniffa,Muzlifah Haniffa,Amanda Shin,Venetia Bigley,Naomi McGovern,Pearline Teo,Peter See,Pavandip Singh Wasan,Xiao-Nong Wang,Frano Malinarich,Benoit Malleret,Anis Larbi,Pearlie W.W. Tan,Helen Zhao,Michael Poidinger,Sarah Pagan,Sharon Cookson,Rachel E. Dickinson,Ian Dimmick,Ruth F. Jarrett,Laurent Rénia,John Siu-Lun Tam,Colin Song,John E. Connolly,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Adam J. Gehring,Antonio Bertoletti,Matthew Collin,Florent Ginhoux +29 more
TL;DR: A CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens was identified.
Journal ArticleDOI
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages
Guillaume Hoeffel,Yilin Wang,Melanie Greter,Peter See,Pearline Teo,Benoit Malleret,Marylene Leboeuf,Donovan Low,Guillaume Oller,Francisca F. Almeida,Sharon H.Y. Choy,Marcos Augusto Grigolin Grisotto,Laurent Rénia,Simon J. Conway,E. Richard Stanley,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Lai Guan Ng,Igor M. Samokhvalov,Miriam Merad,Florent Ginhoux +20 more
TL;DR: Langerhans cell precursors initially arise from yolk sac progenitors, but are later superseded by fetal liver monocytes.
Journal ArticleDOI
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Svetoslav Chakarov,Hwee Ying Lim,Leonard Tan,Sheau Yng Lim,Peter See,Josephine Lum,Xiao Meng Zhang,Shihui Foo,Satoshi Nakamizo,Kaibo Duan,Wan Ting Kong,Rebecca Gentek,Akhila Balachander,Daniel Carbajo,Camille Bleriot,Benoit Malleret,Benoit Malleret,John Kit Chung Tam,Sonia Baig,Muhammad Shabeer,Sue-Anne Ee Shiow Toh,Andreas Schlitzer,Anis Larbi,Thomas Marichal,Bernard Malissen,Jinmiao Chen,Michael Poidinger,Kenji Kabashima,Kenji Kabashima,Marc Bajénoff,Lai Guan Ng,Veronique Angeli,Florent Ginhoux +32 more
TL;DR: In this article, two independent resident tissue macrophages (RTMs) populations are identified across tissues with specific niche-dependent phenotype and functional programming, and they are slowly replaced by Ly6Chi monocytes.
Journal ArticleDOI
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
Andreas Schlitzer,V. Sivakamasundari,Jinmiao Chen,Hermi Sumatoh,Jaring Schreuder,Josephine Lum,Benoit Malleret,Sanqian Zhang,Anis Larbi,Francesca Zolezzi,Laurent Rénia,Michael Poidinger,Shalin H. Naik,Evan W. Newell,Paul Robson,Florent Ginhoux +15 more
TL;DR: This work found that transcriptional signatures of the cDC1 and cDC2 lineages became evident at the single-cell level from the CDP stage, and identified Siglec-H and Ly6C as lineage markers that distinguished pre-DC subpopulations committed to the c DC1 lineage (SigleC-H−Ly6C− pre- DCs) or c DC2 lineage (CDC2 lineage).