C
Chen Liu
Researcher at Rutgers University
Publications - 344
Citations - 21270
Chen Liu is an academic researcher from Rutgers University. The author has contributed to research in topics: Graft-versus-host disease & T cell. The author has an hindex of 72, co-authored 335 publications receiving 18611 citations. Previous affiliations of Chen Liu include University of Tennessee Health Science Center & University of Florida Health Science Center.
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Journal ArticleDOI
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
Alan M. Hanash,Jarrod A Dudakov,Guoqiang Hua,Margaret O'Connor,Lauren F. Young,Natalie V. Singer,Mallory L. West,Robert R. Jenq,Amanda M. Holland,Lucy W. Kappel,Arnab Ghosh,Jennifer Tsai,Uttam K. Rao,Nury L. Yim,Odette M. Smith,Enrico Velardi,Elena B. Hawryluk,George F. Murphy,Chen Liu,Lynette A. Fouser,Richard Kolesnick,Bruce R. Blazar,Marcel R.M. van den Brink +22 more
TL;DR: It is demonstrated here that deficiency of recipient-derived IL-22 increased acute GVHD tissue damage and mortality, that ISCs were eliminated during GV HD, and thatISCs as well as their downstream progenitors expressed the IL- 22 receptor.
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Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics
Guizhi Zhu,Jing Zheng,Jing Zheng,Erqun Song,Erqun Song,Michael J. Donovan,Kejing Zhang,Chen Liu,Weihong Tan,Weihong Tan +9 more
TL;DR: Potent antitumor efficacy and reduced side effects of drugs delivered by biocompatible aptNTrs were demonstrated in a mouse xenograft tumor model, and fluorophores on nanotrains and drug fluorescence dequenching upon release allowed intracellular signaling of nanotRains and drugs.
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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice
Yusuke Shono,Melissa D. Docampo,Jonathan U. Peled,Jonathan U. Peled,Suelen M. Perobelli,Enrico Velardi,Enrico Velardi,Jennifer Tsai,Ann E. Slingerland,Odette M. Smith,Lauren F. Young,Jyotsna Gupta,Sophia R. Lieberman,Hillary V. Jay,Katya F. Ahr,Kori A. Porosnicu Rodriguez,Ke Xu,Marco Calarfiore,Hendrik Poeck,Silvia Caballero,Sean M. Devlin,Franck Rapaport,Jarrod A Dudakov,Jarrod A Dudakov,Alan M. Hanash,Alan M. Hanash,Boglarka Gyurkocza,Boglarka Gyurkocza,George F. Murphy,Camilla Borges Ferreira Gomes,Chen Liu,Eli L. Moss,Shannon B. Falconer,Ami S. Bhatt,Ying Taur,Ying Taur,Eric G. Pamer,Eric G. Pamer,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Robert R. Jenq,Robert R. Jenq +41 more
TL;DR: An underappreciated risk is demonstrated for the treatment of allo-HSCT recipients with antibiotics that may exacerbate GVHD in the colon, and this study suggests that not all antibiotic regimens are appropriate for treating transplant patients.
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Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
Dihua Shangguan,Ling Meng,Zehui Charles Cao,Zeyu Xiao,Xiaohong Fang,Ying Li,Diana M. Cardona,Rafal P Witek,Chen Liu,Weihong Tan +9 more
TL;DR: The current study demonstrates that cell-based aptamer selection can select specific aptamers for multiple cell lines, even for two cell lines with minor differences, and opens the door for solid tumor selection and investigation.
Journal ArticleDOI
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
Pavan Reddy,Yoshinobu Maeda,Kevin B. Hotary,Chen Liu,Leonid L. Reznikov,Charles A. Dinarello,James L.M. Ferrara +6 more
TL;DR: Findings reveal a critical role for histone deacetylase inhibition in the proinflammatory events contributing to GVHD and suggest that this class of pharmacologic agents may provide a strategy to reduce GV HD while preserving cytotoxic T cell responses to host antigens and maintaining beneficial GVL effects.