C
Chen Liu
Researcher at Rutgers University
Publications - 344
Citations - 21270
Chen Liu is an academic researcher from Rutgers University. The author has contributed to research in topics: Graft-versus-host disease & T cell. The author has an hindex of 72, co-authored 335 publications receiving 18611 citations. Previous affiliations of Chen Liu include University of Tennessee Health Science Center & University of Florida Health Science Center.
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Journal ArticleDOI
Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease.
M. Hanief Sofi,Yongxia Wu,Steven Schutt,Min Dai,Anusara Daenthanasanmak,Jessica Heinrichs Voss,Hung Nguyen,David Bastian,Supinya Iamsawat,Shanmugam Panneer Selvam,Chen Liu,Nilanjana Maulik,Besim Ogretmen,Junfei Jin,Shikhar Mehrotra,Xue-Zhong Yu +15 more
TL;DR: The present study found that Trx1-Tg donor T cells or administration of the recipients with RTrx1 significantly reduced GVHD severity and demonstrates feasibility to target the ROS pathway, which can be readily translated into clinic.
Journal ArticleDOI
Successful treatment of chronic hepatitis C with pegylated interferon, ribavirin, and infliximab in a patient with Crohn's disease.
TL;DR: Successful treatment of Chronic Hepatitis C With Pegylated Interferon, Ribavirin, and Infliximab in a Patient with Crohn's Disease is reported.
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A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome.
Gerhard C. Hildebrandt,Gerhard C. Hildebrandt,Krystyna M. Olkiewicz,Leigh A. Corrion,Shawn G. Clouthier,Elizabeth M. Pierce,Chen Liu,Kenneth R. Cooke,Kenneth R. Cooke +8 more
TL;DR: A role for TNF-alpha signaling through TNFRII in leukocyte infiltration into the lung following allo-SCT is demonstrated, and disruption of the T NF-alpha:TNFRII pathway may be an effective tool to prevent or treat IPS.
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Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.
Sydney X. Lu,Amanda M. Holland,Amanda M. Holland,Il-Kang Na,Theis H. Terwey,Onder Alpdogan,Jhoanne L. Bautista,Odette M. Smith,David Suh,Christopher R. King,Adam A. Kochman,Vanessa M. Hubbard,Uttam K. Rao,Nury L. Yim,Chen Liu,Alvaro C. Laga,George F. Murphy,Robert R. Jenq,Johannes L. Zakrzewski,Olaf Penack,Lindsay Dykstra,Kevin Bampoe,Lia E Perez,Bruce Furie,Barbara C. Furie,Marcel R.M. van den Brink +25 more
TL;DR: It is reported that P-selectin, a glycoprotein found on resting and inflamed endothelium, is important for donor alloreactive T cells trafficking into GVHD target organs, such as the intestines and skin, and that targeting P- selectin may be a viable strategy for GV HD prophylaxis or treatment.
Journal ArticleDOI
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer
Daniel Delitto,Chelsey Perez,Song Han,David Hernandez Gonzalo,Kien Pham,Andrea E. Knowlton,Christina L. Graves,Kevin E. Behrns,Lyle L. Moldawer,Ryan M. Thomas,Chen Liu,Thomas J. George,Jose G. Trevino,Shannon M. Wallet,Steven J. Hughes +14 more
TL;DR: It is suggested that IFNγ has multiple effects on many cell types within the PC microenvironment that may lead to immune evasion, chemoresistance and shortened survival.