C
Cheng Wang
Researcher at Nanjing Medical University
Publications - 245
Citations - 9359
Cheng Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Lung cancer & Genome-wide association study. The author has an hindex of 42, co-authored 195 publications receiving 7313 citations. Previous affiliations of Cheng Wang include Tianjin Medical University Cancer Institute and Hospital & Tianjin Medical University.
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Journal ArticleDOI
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA
Lin Zhang,Dongxia Hou,Xi Chen,Donghai Li,Lingyun Zhu,Lingyun Zhu,Yujing Zhang,Jing Li,Zhen Bian,Xiangying Liang,Xing Cai,Yuan Yin,Cheng Wang,Tianfu Zhang,Dihan Zhu,Dianmu Zhang,Jie Xu,Qun Chen,Yi Ba,Jing Liu,Qiang Wang,Jian-Qun Chen,Jin Wang,Meng Wang,Qipeng Zhang,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +27 more
TL;DR: It is shown that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma, demonstrating that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.
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A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis
Rui Liu,Chunni Zhang,Zhibin Hu,Gou Li,Gou Li,Cheng Wang,Cheng Wang,Cuihua Yang,Dingzhi Huang,Dingzhi Huang,Xi Chen,Xi Chen,Haiyang Zhang,Haiyang Zhang,Rui Zhuang,Rui Zhuang,Ting Deng,Ting Deng,Hua Liu,Hua Liu,Jingjing Yin,Jingjing Yin,Sufen Wang,Sufen Wang,Ke Zen,Ke Zen,Yi Ba,Yi Ba,Chen-Yu Zhang,Chen-Yu Zhang +29 more
TL;DR: This study identified a serum microRNA expression profile that can serve as a novel diagnostic biomarker for GC detection and assess its clinical applications in monitoring disease progression.
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin,Chunlai Li,Zhen Xing,Qingsong Hu,Ke Liang,Leng Han,Cheng Wang,David H. Hawke,Shouyu Wang,Yanyan Zhang,Yongkun Wei,Guolin Ma,Peter K. Park,Jianwei Zhou,Yan Zhou,Zhibin Hu,Yubin Zhou,Jeffery R. Marks,Han Liang,Mien Chie Hung,Chunru Lin,Liuqing Yang +21 more
TL;DR: A cytoplasmic lncRNA is identified, LINK-A, which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively, and correlates with triple-negative breast cancer (TNBC), promoting breast cancer glycolysis reprogramming and tumorigenesis.
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Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer
Rui Liu,Rui Liu,Xi Chen,Xi Chen,Yiqi Du,Weiyan Yao,Lin Shen,Cheng Wang,Cheng Wang,Zhibin Hu,Rui Zhuang,Rui Zhuang,Guang Ning,Chunni Zhang,Yaozong Yuan,Zhao-Shen Li,Ke Zen,Ke Zen,Yi Ba,Chen-Yu Zhang,Chen-Yu Zhang +20 more
TL;DR: This 7 miRNA-based biomarker had high sensitivity and specificity for distinguishing various stages of PaC from cancer-free controls and also accurately discriminated PaC patients from chronic pancreatitis (CP) patients.
Journal ArticleDOI
Expression Profile of MicroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma
Chunni Zhang,Cheng Wang,Xi Chen,Cuihua Yang,Ke Li,Junjun Wang,Juncheng Dai,Zhibin Hu,Xiaojun Zhou,Longbang Chen,Yanni Zhang,Yanfang Li,Hong Qiu,Jicheng Xing,Zhichao Liang,Binhui Ren,Chen Yang,Ke Zen,Chen-Yu Zhang +18 more
TL;DR: This panel of 7 serum miRNAs holds promise as a novel blood-based biomarker for the diagnosis of ESCC, and clearly distinguished stage I/II ESCC patients from controls.