Chris Haley

TL;DR: The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition, and the genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.

TL;DR: This paper developed a least square method for the analysis of crosses between outbred lines which simultaneously uses information from multiple linked markers, which is suitable for crosses where the lines may be segregating at marker loci but can be assumed to be fixed for alternative alleles at the major quantitative trait loci affecting the traits under analysis.

TL;DR: The determination of empirical confidence intervals for the location of quantitative trait loci (QTLs) was investigated using simulation using a bootstrap resampling method for a backcross population derived from inbred lines, and confidence intervals were slightly conservatively biased.

TL;DR: QTL Express is the first application for Quantitative Trait Locus mapping in outbred populations with a web-based user interface that allows mapping of single or multiple QTL by the regression approach, with the option to perform permutation or bootstrap tests.

TL;DR: A novel approach for genomewide pedigree-based quantitative trait loci (QTL) association analysis:genomewide rapid association using mixed model and regression (GRAMMAR), which first obtains residuals adjusted for family effects and subsequently analyzes the association between residuals and genetic polymorphisms using rapid least-squares methods.