C
Chris Haley
Researcher at University of Edinburgh
Publications - 427
Citations - 26040
Chris Haley is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Quantitative trait locus & Population. The author has an hindex of 71, co-authored 410 publications receiving 23592 citations. Previous affiliations of Chris Haley include Medical Research Council & The Roslin Institute.
Papers
More filters
Journal ArticleDOI
Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer cross.
A. Sewalem,D M Morrice,Andy Law,D Windsor,Chris Haley,C.O.N. Ikeobi,David W. Burt,Paul M Hocking +7 more
TL;DR: An F2 chicken population was established from a cross of a broiler sire-line and an egg laying (White Leghorn) line, and genetic effects were generally additive, and the broiler allele increased body weight in all cases.
Journal ArticleDOI
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Qian Zhang,Costanza L. Vallerga,Rosie M. Walker,Tian Lin,Anjali K. Henders,Grant W. Montgomery,Ji He,Dongsheng Fan,Javed Fowdar,Martin A. Kennedy,Toni L. Pitcher,John F. Pearson,Glenda M. Halliday,John B.J. Kwok,Ian B. Hickie,Simon J.G. Lewis,Tim J. Anderson,Peter A. Silburn,George D. Mellick,Sarah E. Harris,Paul Redmond,Alison D. Murray,David J. Porteous,Chris Haley,Kathryn L. Evans,Andrew M. McIntosh,Andrew M. McIntosh,Jian Yang,Jacob Gratten,Riccardo E. Marioni,Naomi R. Wray,Ian J. Deary,Allan F. McRae,Peter M. Visscher +33 more
TL;DR: This study indicates that the epigenetic clock can be improved by increasing the training sample size and that its association with mortality attenuates with increased prediction of chronological age.
Journal ArticleDOI
Maximum likelihood mapping of quantitative trait loci using full-sib families.
Sara Knott,Chris Haley +1 more
TL;DR: A maximum likelihood method is presented for the detection of quantitative trait loci (QTL) using flanking markers in full-sib families and this method incorporates a random component for common family effects due to additional QTL or the environment.
Journal ArticleDOI
Genetical genomics in humans and model organisms
Dirk-Jan de Koning,Chris Haley +1 more
TL;DR: It is concluded that, although the studies in model species successfully demonstrate the utility of genetical genomics, they are too limited to unlock the full potential of this approach and some results should be interpreted with caution.
Journal ArticleDOI
Directional dominance on stature and cognition in diverse human populations
Peter K. Joshi,Tõnu Esko,Hannele Mattsson,Niina Eklund,Ilaria Gandin,Teresa Nutile,Anne U. Jackson,Claudia Schurmann,Albert V. Smith,Weihua Zhang,Yukinori Okada,Alena Stančáková,Jessica D. Faul,Wei Zhao,Traci M. Bartz,Maria Pina Concas,Nora Franceschini,Stefan Enroth,Veronique Vitart,Stella Trompet,Xiuqing Guo,Daniel I. Chasman,Jeffrey R. O'Connel,Tanguy Corre,Suraj S. Nongmaithem,Yuning Chen,Massimo Mangino,Daniela Ruggiero,Michela Traglia,Aliki-Eleni Farmaki,Tim Kacprowski,Andrew Bjonnes,Ashley van der Spek,Ying Wu,Anil K. Giri,Lisa R. Yanek,Lihua Wang,Edith Hofer,Cornelius A. Rietveld,Olga McLeod,Marilyn C. Cornelis,Cristian Pattaro,Niek Verweij,Clemens Baumbach,Abdel Abdellaoui,Helen R. Warren,Dragana Vuckovic,Hao Mei,Claude Bouchard,John R. B. Perry,Stefania Cappellani,Saira Saeed Mirza,Miles C. Benton,Ulrich Broeckel,Sarah E. Medland,Penelope A. Lind,Giovanni Malerba,Alexander W. Drong,Loic Yengo,Lawrence F. Bielak,Degui Zhi,Peter J. van der Most,Daniel Shriner,Reedik Mägi,Gibran Hemani,Tugce Karaderi,Zhaoming Wang,Tian Liu,Ilja Demuth,Jing Hua Zhao,Weihua Meng,Lazaros Lataniotis,Sander W. van der Laan,Jonathan P. Bradfield,Andrew R. Wood,Amélie Bonnefond,Tarunveer S. Ahluwalia,Leanne M. Hall,Erika Salvi,Seyhan Yazar,Lisbeth Carstensen,Hugoline G. de Haan,Mark Abney,Uzma Afzal,Matthew A. Allison,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,R. Graham Barr,Sebastian E. Baumeister,Daniel J. Benjamin,Sven Bergmann,Eric Boerwinkle,Erwin P. Bottinger,Archie Campbell,Aravinda Chakravarti,Yingleong Chan,Stephen J. Chanock,Constance Chen,Y.-D. Ida Chen,Francis S. Collins,John M. C. Connell,Adolfo Correa,L. Adrienne Cupples,George Davey Smith,Gail Davies,Marcus Dörr,Georg Ehret,Stephen B. Ellis,Bjarke Feenstra,Mary F. Feitosa,Ian Ford,Caroline S. Fox,Timothy M. Frayling,Nele Friedrich,Frank Geller,Generation Scotland,Irina Gillham-Nasenya,Omri Gottesman,Misa Graff,Francine Grodstein,Charles Gu,Chris Haley,Christopher J Hammond,Sarah E. Harris,Tamara B. Harris,Nicholas D. Hastie,Nancy L. Heard-Costa,Kauko Heikkilä,Lynne J. Hocking,Georg Homuth,Jouke-Jan Hottenga,Jinyan Huang,Jennifer E. Huffman,Pirro G. Hysi,M. Arfan Ikram,Erik Ingelsson,Anni Joensuu,Åsa Johansson,Pekka Jousilahti,J. Wouter Jukema,Mika Kähönen,Yoichiro Kamatani,Stavroula Kanoni,Shona M. Kerr,Nazir M. Khan,Philipp Koellinger,Heikki A. Koistinen,Manraj K. Kooner,Michiaki Kubo,Johanna Kuusisto,Jari Lahti,Lenore J. Launer,Rodney A. Lea,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Lars Lind,Marie Loh,Marja-Liisa Lokki,Stephanie J. London,Stephanie J. Loomis,Anu Loukola,Yingchang Lu,Thomas Lumley,Annamari Lundqvist,Satu Männistö,Pedro Marques-Vidal,Corrado Masciullo,Angela Matchan,Rasika A. Mathias,Koichi Matsuda,James B. Meigs,Christa Meisinger,Thomas Meitinger,Cristina Menni,Frank D. Mentch,Evelin Mihailov,Lili Milani,May E. Montasser,Grant W. Montgomery,Alanna C. Morrison,Richard H. Myers,Rajiv Nadukuru,Pau Navarro,Mari Nalis,Markku S. Nieminen,Ilja M. Nolte,George T. O'Connor,Adesola Ogunniyi,Sandosh Padmanabhan,Walter Palmas,James S. Pankow,Inga Patarčić,Francesca Pavani,Patricia A. Peyser,Kirsi H. Pietiläinen,Neil R Poulter,Inga Prokopenko,Sarju Ralhan,Paul Redmond,Stephen S. Rich,Harri Rissanen,Antonietta Robino,Lynda M. Rose,Richard J. Rose,Cinzia Sala,Babatunde L. Salako,Veikko Salomaa,Antti-Pekka Sarin,Richa Saxena,Helena Schmidt,Laura J. Scott,William R. Scott,Bengt Sennblad,Sudha Seshadri,Peter S. Sever,Smeeta Shrestha,Blair H. Smith,Jennifer A. Smith,Nicole Soranzo,Nona Sotoodehnia,Lorraine Southam,Alice Stanton,Maria G. Stathopoulou,Konstantin Strauch,Rona J. Strawbridge,Matthew Suderman,Nikhil Tandon,Sian Tsun Tang,Kent D. Taylor,Bamidele O. Tayo,Anna Maria Töglhofer,Maciej Tomaszewski,Natalia Tšernikova,Jaakko Tuomilehto,André G. Uitterlinden,Dhananjay Vaidya,Astrid van Hylckama Vlieg,Jessica van Setten,Tuula Vasankari,Sailaja Vedantam,Efthymia Vlachopoulou,Diego Vozzi,Eero Vuoksimaa,Melanie Waldenberger,Erin B. Ware,William Wentworth-Shields,John Whitfield,Sarah H. Wild,Gonneke Willemsen,Chittaranjan S. Yajnik,Jie Yao,Gianluigi Zaza,Xiaofeng Zhu,Rany M. Salem,Mads Melbye,Hans Bisgaard,Nilesh J. Samani,Daniele Cusi,David A. Mackey,Richard S. Cooper,Philippe Froguel,Gerard Pasterkamp,Struan F.A. Grant,Hakon Hakonarson,Luigi Ferrucci,Robert A. Scott,Andrew D. Morris,Colin N. A. Palmer,George Dedoussis,Panos Deloukas,Lars Bertram,Ulman Lindenberger,Sonja I. Berndt,Cecilia M. Lindgren,Nicholas J. Timpson,Anke Tönjes,Patricia B. Munroe,Thorkild I. A. Sørensen,Charles N. Rotimi,Donna K. Arnett,Albertine J. Oldehinkel,Sharon L.R. Kardia,Beverley Balkau,Giovanni Gambaro,Andrew P. Morris,Johan G. Eriksson,Margie Wright,Nicholas G. Martin,Steven C. Hunt,John M. Starr,Ian J. Deary,Lyn R. Griffiths,Henning Tiemeier,Nicola Pirastu,Jaakko Kaprio,Nicholas J. Wareham,Louis Pérusse,James G. Wilson,Giorgia Girotto,Mark J. Caulfield,Olli T. Raitakari,Dorret I. Boomsma,Christian Gieger,Pim van der Harst,Andrew A. Hicks,Peter Kraft,Juha Sinisalo,Paul Knekt,Magnus Johannesson,Patrik K. E. Magnusson,Anders Hamsten,Reinhold Schmidt,Ingrid B. Borecki,Erkki Vartiainen,Diane M. Becker,Dwaipayan Bharadwaj,Karen L. Mohlke,Michael Boehnke,Cornelia M. van Duijn,Dharambir K. Sanghera,Alexander Teumer,Eleftheria Zeggini,Andres Metspalu,Paolo Gasparini,Sheila Ulivi,Carole Ober,Daniela Toniolo,Igor Rudan,David J. Porteous,Marina Ciullo,Tim D. Spector,Caroline Hayward,Josée Dupuis,Ruth J. F. Loos,Alan F. Wright,Giriraj R. Chandak,Peter Vollenweider,Alan R. Shuldiner,Paul M. Ridker,Jerome I. Rotter,Naveed Sattar,Ulf Gyllensten,Kari E. North,Mario Pirastu,Bruce M. Psaty,David R. Weir,Markku Laakso,Vilmundur Gudnason,Atsushi Takahashi,John C. Chambers,Jaspal S. Kooner,David P. Strachan,Harry Campbell,Joel N. Hirschhorn,Markus Perola,Ozren Polasek,James F. Wilson +358 more
TL;DR: This study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.