C
Chris Haley
Researcher at University of Edinburgh
Publications - 427
Citations - 26040
Chris Haley is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Quantitative trait locus & Population. The author has an hindex of 71, co-authored 410 publications receiving 23592 citations. Previous affiliations of Chris Haley include Medical Research Council & The Roslin Institute.
Papers
More filters
Journal Article
The potential role of molecular genetic manipulation in the improvement of reproductive performance.
TL;DR: A review of the potential application of these procedures for the improvement of reproductive performance in livestock can be found in this article, where a consideration of the methods of molecular manipulation that are available at present and those that seem likely to become available, a discussion of the modifications to hormonal systems and, finally, an analysis of candidate genes for manipulation of seasonality, number of ovulations, sex ratio and prenatal survival.
Journal ArticleDOI
Comparative transcriptome in large-scale human and cattle populations
Yue Yao,Shuli Liu,Charley Xia,Yahui Gao,Zhangyuan Pan,Oriol Canela-Xandri,Ava Khamseh,Konrad Rawlik,Sheng Wang,Bingjie Li,Yi Zhang,Erola Pairo-Castineira,K. D'Mellow,Xiujin Li,Ze Yan,Congjun Li,Ying Yu,Shengli Zhang,Li Ma,John B. Cole,Pablo J. Ross,Huaijun Zhou,Chris Haley,George E. Liu,Lingzhao Fang,Albert Tenesa +25 more
TL;DR: In this paper , a cross-species comparison of transcriptomes between humans and cattle was conducted to elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, which can help decipher the genetic and evolutionary basis of complex traits in both species.
Journal ArticleDOI
Antagonistic genetic correlations for milking traits within the genome of dairy cattle
TL;DR: Positive genomic correlations between loci are consistent with the negative linkage disequilibrium expected for traits under directional selection, and antagonistic correlations could hamper the fixation of major genes under intensive selection.
Journal ArticleDOI
Including copy number variation in association studies to predict genotypic values.
TL;DR: Investigation of the ability to explain genetic variation resulting from a copy number polymorphism by including the CNP, either by its genotype or by a continuous derivation thereof, alone or together with a nearby single nucleotide polymorphism (SNP) in the model showed that the linkage disequilibrium between an SNP and CNP was lower than LD between two SNPs.
Posted ContentDOI
Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer
Ryan Langdon,Rebecca C Richmond,Hannah R Elliott,Tom Dudding,Nabila Kazmi,C. Penfold,Kate Ingarfield,Karen M Ho,Andrew D. Bretherick,Chris Haley,Yanni Zeng,Rosie M. Walker,Michael Pawlita,Tim Waterboer,Susan M. Ring,Tom R. Gaunt,George Davey Smith,Matthew Suderman,Steve J Thomas,Andy R Ness,Caroline L Relton +20 more
TL;DR: The authors conducted epigenome-wide association studies (EWAS) of these factors and 3-year survival using Illumina Methylation EPIC blood DNA methylation profiles from 409 individuals in the Head and Neck 5000 (HN5000) study.