C
Christian Schrøder Kaas
Researcher at Novo Nordisk
Publications - 18
Citations - 475
Christian Schrøder Kaas is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Chinese hamster ovary cell & Gene. The author has an hindex of 8, co-authored 17 publications receiving 400 citations. Previous affiliations of Christian Schrøder Kaas include Harvard University & Johns Hopkins University.
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Journal ArticleDOI
A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans.
Rebecca S. Shapiro,Rebecca S. Shapiro,Rebecca S. Shapiro,Alejandro Chavez,Caroline B. M. Porter,Caroline B. M. Porter,Meagan Hamblin,Christian Schrøder Kaas,Christian Schrøder Kaas,Christian Schrøder Kaas,James E. DiCarlo,James E. DiCarlo,Guisheng Zeng,Xiaoli Xu,Alexey V. Revtovich,Natalia V. Kirienko,Yue Wang,Yue Wang,George M. Church,George M. Church,James J. Collins,James J. Collins,James J. Collins +22 more
TL;DR: In this article, a CRISPR-Cas9-based "gene drive array" platform was developed to facilitate efficient genetic analysis in C. albicans, where a modified DNA donor molecule acts as a selfish genetic element, replacing the targeted site and propagates to replace additional wild-type loci.
Journal ArticleDOI
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.
Xiaoge Guo,Alejandro Chavez,Angela Tung,Yingleong Chan,Yingleong Chan,Christian Schrøder Kaas,Christian Schrøder Kaas,Christian Schrøder Kaas,Yi Yin,Ryan J Cecchi,Santiago Lopez Garnier,Eric D. Kelsic,Eric D. Kelsic,Max G. Schubert,Max G. Schubert,James E. DiCarlo,James E. DiCarlo,James E. DiCarlo,James J. Collins,George M. Church,George M. Church +20 more
TL;DR: In this article, a Cas9-based approach for generating pools of mutants with defined genetic alterations (deletions, substitutions, and insertions) with an efficiency of 80-100% in yeast, along with methods for tracking their fitness en masse.
Journal ArticleDOI
Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy
Christian Schrøder Kaas,Christian Schrøder Kaas,Christian Schrøder Kaas,Claus Kristensen,Michael J. Betenbaugh,Mikael Rørdam Andersen +5 more
TL;DR: An unexpected degree of haploidy is revealed in CHO DXB11 and CHO cells in general and the data indicate that chromosome one and four appear to be more stable over the course of the CHO evolution compared to the other chromosomes thus might presenting the most attractive landing platforms for knock-ins of heterologous genes.
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
Rebecca S. Shapiro,Rebecca S. Shapiro,Rebecca S. Shapiro,Alejandro Chavez,Caroline B. M. Porter,Caroline B. M. Porter,Meagan Hamblin,Christian Schrøder Kaas,Christian Schrøder Kaas,Christian Schrøder Kaas,James E. DiCarlo,James E. DiCarlo,Guisheng Zeng,Xiaoli Xu,Alexey V. Revtovich,Natalia V. Kirienko,Yue Wang,Yue Wang,George M. Church,George M. Church,James J. Collins,James J. Collins,James J. Collins +22 more
TL;DR: A CRISPR–Cas9-based gene drive array platform is developed and combined with mating-competent Candida albicans haploids to generate homozygous double-deletion mutants, transforming the ability to do genetic interaction analyses in fungi.
Journal ArticleDOI
A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi
Bjarne Gram Hansen,Bjarne Gram Hansen,Hans Jasper Genee,Christian Schrøder Kaas,Jakob Blæsbjerg Nielsen,Torsten Bak Regueira,Torsten Bak Regueira,Uffe Hasbro Mortensen,Jens Christian Frisvad,Kiran Raosaheb Patil,Kiran Raosaheb Patil +10 more
TL;DR: Heterologous expression of mpaF dramatically increased MPA resistance in a model fungus, Aspergillus nidulans, which does not produce MPA, and identified a novel variant of the IMPDH-encoding gene in six different strains from Penicillium subgenus Penicllium.