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Christina Bauer
Researcher at Center for Integrated Protein Science Munich
Publications - 6
Citations - 1148
Christina Bauer is an academic researcher from Center for Integrated Protein Science Munich. The author has contributed to research in topics: DNA demethylation & Phosphorylation. The author has an hindex of 5, co-authored 6 publications receiving 1047 citations. Previous affiliations of Christina Bauer include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
Journal ArticleDOI
Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)
Christina Bauer,Klaus Göbel,Nagarjuna Nagaraj,Christian Colantuoni,Mengxi Wang,Udo Müller,Elisabeth Kremmer,Andrea Rottach,Heinrich Leonhardt,Heinrich Leonhardt +9 more
TL;DR: The results provide a novel potential mechanism for TET protein regulation based on a dynamic interplay of phosphorylation and O-GlcNAcylation at the N terminus and the low-complexity insert region.
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TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
TL;DR: Results clearly show that oxidation of methylcytosine by TET dioxygenases and subsequent removal by TDG or NEIL glycosylases and the BER pathway results in reactivation of epigenetically silenced genes.
Journal ArticleDOI
A modular open platform for systematic functional studies under physiological conditions
Christopher B. Mulholland,Martha Smets,Elisabeth Schmidtmann,Susanne Leidescher,Yolanda Markaki,Mario Hofweber,Weihua Qin,Massimiliano Manzo,Elisabeth Kremmer,Katharina Thanisch,Christina Bauer,Pascaline Rombaut,Franz Herzog,Heinrich Leonhardt,Sebastian Bultmann +14 more
TL;DR: A multifunctional integrase (MIN) tag for rapid and versatile genome engineering is developed that serves not only as a genetic entry site for the Bxb1 integrase but also as a novel epitope tag for standardized detection and precipitation.
Journal ArticleDOI
Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads.
Markus Schneider,Carina Trummer,Andreas Stengl,Peng Zhang,Peng Zhang,Aleksandra Szwagierczak,M. Cristina Cardoso,Heinrich Leonhardt,Christina Bauer,Iris Antes +9 more
TL;DR: The results suggest a possible additional function of the hemi-methylation reader UHRF1 through binding of carboxylated CpG sites, which opens the possibility of new biological roles of U HRF1 beyond DNA methylation maintenance and of oxidised methylcytosine derivates in epigenetic regulation.