Christine A. White

TL;DR: In this paper, an extensive review of the literature found that GFR declines with healthy aging without any overt signs of compensation (such as elevated single-nephron GFR) or kidney damage.

TL;DR: The CKD-EPI equation shows improved estimation ability, and it is recommended that it replace the MDRD Study equation as the currently preferred creatinine-based estimating equation for KTRs.

TL;DR: Differences in patient populations, baseline GFRs of the study group, reference standard GFR used, and creatinine assay calibration likely account for the heterogeneity in results.

TL;DR: Treatment with ramipril compared with placebo did not lead to a significant reduction in doubling of serum creatinine, end-stage renal disease, or death in kidney transplant recipients with proteinuria and the use of angiotensin-converting enzyme inhibitors is not supported.

TL;DR: An overview of the biochemistry, physiology and metabolism, biological functions, and measurement of BTP is provided; the evidence for BTP as a marker of both kidney function and cardiovascular disease is summarized; and the interplay between its biological properties, serum concentration, and patient outcomes is considered.