Christine L. Zimmer

TL;DR: Interestingly, T cells of patients that subsequently achieve hepatitis B surface antigen loss are less exhausted at all time-points after stopping treatment and display a higher proliferative capacity 12-weeks after treatment discontinuation, which contributes to the understanding of the immunological events that occur during discontinuation of nucleos(t)ide analogue therapy.

TL;DR: It is found that in patients with HDV, a subset of innate-like T cells called mucosa-associated invariant T cells (or MAIT cells), which are normally abundant in peripheral blood and the liver, are activated, functionally impaired and severely depleted.

TL;DR: Increased NK cell function is associated with active hepatitis and HBsAg seroclearance following structured NA cessation, and this adds to the knowledge of the immunological events that develop following cessation of NA treatment in CHB.

TL;DR: The presence of disease-specific changes within circulating and tissue-resident NK cell populations, as well as within other major immune cell subsets, in patients with liver biopsy-confirmed NAFLD is explored and the importance of the local microenvironment in shaping the NK cell compartment is increased.

TL;DR: Evidence is provided of an IL-18-driven NK cell proliferation and priming for skin-homing during an acute viral infection in humans and the data suggest thatNK cell proliferation depends on IL- 18 signaling, and that responding NK cells have a skin-Homing phenotype.