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Christine Moussion
Researcher at Genentech
Publications - 25
Citations - 2861
Christine Moussion is an academic researcher from Genentech. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 11, co-authored 19 publications receiving 2312 citations. Previous affiliations of Christine Moussion include University of Toulouse & Georgia Institute of Technology.
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Journal ArticleDOI
The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo : A Novel ‘Alarmin’?
Christine Moussion,Nathalie Ortega,Nathalie Ortega,Jean-Philippe Girard,Jean-Philippe Girard +4 more
TL;DR: It is speculated that IL-33 may function, similarly to the prototype ‘alarmin’ HMGB1, as an endogenous ‘danger’ signal to alert the immune system after endothelial or epithelial cell damage during trauma or infection.
Journal ArticleDOI
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
Jean-Philippe Girard,Christine Moussion,Christine Moussion,Christine Moussion,Reinhold Förster +4 more
TL;DR: The current understanding of the functions of high endothelial venules, stroma and lymphatics in the entry, positioning and exit of immune cells in lymph nodes during homeostasis are reviewed, and the unexpected role of dendritic cells is highlighted in the control of lymphocyte homing through HEVs.
Journal ArticleDOI
Interstitial dendritic cell guidance by haptotactic chemokine gradients.
Michele Weber,Robert Hauschild,Jan Schwarz,Christine Moussion,Ingrid de Vries,Daniel F. Legler,Sanjiv A. Luther,Tobias Bollenbach,Michael Sixt +8 more
TL;DR: These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.
Journal ArticleDOI
Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
TL;DR: Dendritic cells, which are well known for their role in antigen presentation to T lymphocytes, control the entry of naive lymphocytes to lymph nodes by modulating the phenotype of high endothelial venules (HEVs), which are blood vessels specialized in lymphocyte recruitment.
Journal ArticleDOI
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
Maria Casanova-Acebes,Erica Dalla,Andrew Leader,Jessica LeBerichel,Jovan Nikolic,Blanca M. Morales,Markus Brown,Christie Chang,Leanna Troncoso,Steven T. Chen,Ana Sastre-Perona,Matthew D. Park,Alexandra Tabachnikova,Maxime Dhainaut,Pauline Hamon,Barbara Maier,Catherine M. Sawai,Esperanza Agulló-Pascual,Markus Schober,Brian D. Brown,Boris Reizis,Thomas U. Marron,Ephraim Kenigsberg,Christine Moussion,Philippe Benaroch,Julio A. Aguirre-Ghiso,Miriam Merad +26 more
TL;DR: In this article, single-cell RNA sequencing and imaging of macrophages in human non-small cell lung cancer and in a mouse model of lung adenocarcinoma was performed.