Tobias Bollenbach

TL;DR: These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.

TL;DR: The cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking, and the range is controlled by the four key kinetic parameters governing morphogen spreading.

TL;DR: A fluorescence decay after photoactivation assay is established to quantitatively study the kinetic behaviour of Oct4, a key transcription factor controlling pre-implantation development in the mouse embryo and identifies Oct4 kinetics, rather than differences in total transcription factor expression levels, as a predictive measure of developmental cell lineage patterning in the early mouse embryo.

TL;DR: Using GFP-tagged transcription reporters in Escherichia coli, it is found that ribosomal genes are not directly regulated by DNA stress, leading to an imbalance between cellular DNA and protein content, and a simple mathematical model explains the nonoptimal regulation in different nutrient environments.

TL;DR: The conceptual and technical foundation for the rational design of potent drug combinations is rapidly developing and new treatment strategies that use drug combinations to exploit evolutionary tradeoffs were shown to affect the rate of resistance evolution in predictable ways.