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Steffen Tiedt
Researcher at Ludwig Maximilian University of Munich
Publications - 75
Citations - 3104
Steffen Tiedt is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Stroke & Medicine. The author has an hindex of 16, co-authored 53 publications receiving 1889 citations. Previous affiliations of Steffen Tiedt include University of Texas Health Science Center at Houston.
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik,Ganesh Chauhan,Matthew Traylor,Muralidharan Sargurupremraj,Yukinori Okada,Aniket Mishra,Loes C.A. Rutten-Jacobs,Anne-Katrin Giese,Sander W. van der Laan,Solveig Gretarsdottir,Christopher D. Anderson,Michael Chong,Hieab H.H. Adams,Tetsuro Ago,Peter Almgren,Philippe Amouyel,Hakan Ay,Traci M. Bartz,Oscar R. Benavente,Steve Bevan,Giorgio B. Boncoraglio,Robert D. Brown,Adam S. Butterworth,Caty Carrera,Cara L. Carty,Daniel I. Chasman,Wei-Min Chen,John W. Cole,Adolfo Correa,Ioana Cotlarciuc,Carlos Cruchaga,John Danesh,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Rebecca F. Gottesman,Raji P. Grewal,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Tamara B. Harris,Ahamad Hassan,Aki S. Havulinna,Susan R. Heckbert,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Hyacinth I. Hyacinth,M. Arfan Ikram,Erik Ingelsson,Marguerite R. Irvin,Xueqiu Jian,Jordi Jimenez-Conde,Julie A. Johnson,J. Wouter Jukema,Masahiro Kanai,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Charles Kooperberg,Michiaki Kubo,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Jin-Moo Lee,Robin Lemmens,Didier Leys,Cathryn M. Lewis,Wei-Yu Lin,Arne Lindgren,Erik Lorentzen,Patrik K. E. Magnusson,Jane Maguire,Ani Manichaikul,Patrick F. McArdle,James F. Meschia,Braxton D. Mitchell,Thomas H. Mosley,Mike A. Nalls,Toshiharu Ninomiya,Martin O'Donnell,Bruce M. Psaty,Sara L. Pulit,Kristiina Rannikmäe,Alexander P. Reiner,Kathryn M. Rexrode,Kenneth Rice,Stephen S. Rich,Paul M. Ridker,Natalia S. Rost,Peter M. Rothwell,Jerome I. Rotter,Tatjana Rundek,Ralph L. Sacco,Saori Sakaue,Michèle M. Sale,Veikko Salomaa,Bishwa Raj Sapkota,Reinhold Schmidt,Carsten Oliver Schmidt,Ulf Schminke,Pankaj Sharma,Agnieszka Slowik,Cathie Sudlow,Christian Tanislav,Turgut Tatlisumak,Kent D. Taylor,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Steffen Tiedt,Stella Trompet,Christophe Tzourio,Cornelia M. van Duijn,Matthew Walters,Nicholas J. Wareham,Sylvia Wassertheil-Smoller,James G. Wilson,Kerri L. Wiggins,Qiong Yang,Salim Yusuf,Joshua C. Bis,Tomi Pastinen,Arno Ruusalepp,Eric E. Schadt,Simon Koplev,Johan Björkegren,Veronica Codoni,Mete Civelek,Nicholas L. Smith,David A. Tregouet,Ingrid E. Christophersen,Carolina Roselli,Steven A. Lubitz,Patrick T. Ellinor,E. Shyong Tai,Jaspal S. Kooner,Norihiro Kato,Jiang He,Pim van der Harst,Paul Elliott,John C. Chambers,Fumihiko Takeuchi,Andrew D. Johnson,Dharambir K. Sanghera,Olle Melander,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,W. T. Longstreth,Arndt Rolfs,Jun Hata,Daniel Woo,Jonathan Rosand,Guillaume Paré,Jemma C. Hopewell,Danish Saleheen,Kari Stefansson,Bradford B. Worrall,Steven J. Kittner,Sudha Seshadri,Myriam Fornage,Hugh S. Markus,Joanna M. M. Howson,Yoichiro Kamatani,Stéphanie Debette,Martin Dichgans +170 more
TL;DR: A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
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Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Christophe Heinrich,Robert Blum,Susan Gascon,Giacomo Masserdotti,Pratibha Tripathi,Rodrigo Vega Sánchez,Steffen Tiedt,Timm Schroeder,Magdalena Götz,Magdalena Götz,Benedikt Berninger +10 more
TL;DR: Forced expression of single defined transcription factors can selectively and stably convert cultured astroglia into synapse-forming excitatory and inhibitory neurons.
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
Swetlana Sirko,Gwendolyn Behrendt,Pia A Johansson,Pratibha Tripathi,Marcos R. Costa,Sarah Bek,Christophe Heinrich,Steffen Tiedt,Dilek Colak,Martin Dichgans,Isabel Rebekka Fischer,Nikolaus Plesnila,Matthias Staufenbiel,Christian Haass,Christian Haass,Marina Snapyan,Armen Saghatelyan,Li-Huei Tsai,Li-Huei Tsai,Andre Fischer,Kay Grobe,Leda Dimou,Magdalena Götz +22 more
TL;DR: These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
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Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit,Patrick F. McArdle,Quenna Wong,Rainer Malik,Katrina Gwinn,Sefanja Achterberg,Ale Algra,Philippe Amouyel,Christopher D. Anderson,Donna K. Arnett,Ethem Murat Arsava,John Attia,Hakan Ay,Traci M. Bartz,Thomas W.K. Battey,Oscar R. Benavente,Steve Bevan,Alessandro Biffi,Joshua C. Bis,Susan H. Blanton,Giorgio B. Boncoraglio,Robert D. Brown,Annette I. Burgess,Caty Carrera,Sherita N Chapman Smith,Daniel I. Chasman,Ganesh Chauhan,Wei-Min Chen,Yu-Ching Cheng,Michael Chong,Lisa Cloonan,John W. Cole,Ioana Cotlarciuc,Carlos Cruchaga,Elisa Cuadrado-Godia,Tushar Dave,Jesse Dawson,Stéphanie Debette,Hossein Delavaran,Cameron A Dell,Martin Dichgans,Kimberly F. Doheny,Chuanhui Dong,David Duggan,Gunnar Engström,Michele K. Evans,Xavier Estivill Pallejà,Jessica D. Faul,Israel Fernandez-Cadenas,Myriam Fornage,Philippe M. Frossard,Karen L. Furie,Dale M Gamble,Christian Gieger,Anne-Katrin Giese,Eva Giralt-Steinhauer,Hector M. González,An Goris,Solveig Gretarsdottir,Raji P. Grewal,Ulrike Grittner,Stefan Gustafsson,Buhm Han,Graeme J. Hankey,Laura Heitsch,Peter Higgins,Marc C. Hochberg,Elizabeth G. Holliday,Jemma C. Hopewell,Richard B. Horenstein,George Howard,M. Arfan Ikram,Andreea Ilinca,Erik Ingelsson,Marguerite R. Irvin,Rebecca D. Jackson,Christina Jern,Jordi Jimenez Conde,Julie A. Johnson,Katarina Jood,Muhammad S Kahn,Robert C. Kaplan,L. Jaap Kappelle,Sharon L.R. Kardia,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Simon A. Koblar,Daniel L. Labovitz,Lenore J. Launer,Cathy C. Laurie,Cecelia A. Laurie,Cue Hyunkyu Lee,Jin-Moo Lee,Manuel Lehm,Robin Lemmens,Christopher Levi,Didier Leys,Arne Lindgren,W. T. Longstreth,Jane Maguire,Ani Manichaikul,Hugh S. Markus,Leslie A. McClure,Caitrin W. McDonough,Christa Meisinger,Olle Melander,James F. Meschia,Marina Mola-Caminal,Joan Montaner,Thomas H. Mosley,Martina Müller-Nurasyid,Mike A. Nalls,Jeffrey R. O'Connell,Martin O'Donnell,Angel Ois,George J. Papanicolaou,Guillaume Paré,Leema Reddy Peddareddygari,Annie Pedersen,Joanna Pera,Annette Peters,D Poole,Bruce M. Psaty,Raquel Rabionet,Miriam R. Raffeld,Kristiina Rannikmäe,Asif Rasheed,Petra Redfors,Alexander P. Reiner,Kathryn M. Rexrode,Marta Ribasés,Stephen S. Rich,Wim Robberecht,Ana Rodríguez-Campello,Arndt Rolfs,Jaume Roquer,Lynda M. Rose,Daniel Rosenbaum,Natalia S. Rost,Peter M. Rothwell,Tatjana Rundek,Kathleen A. Ryan,Ralph L. Sacco,Michèle M. Sale,Danish Saleheen,Veikko Salomaa,Cristina Sánchez-Mora,Carsten Oliver Schmidt,Helena Schmidt,Reinhold E. Schmidt,Markus Schürks,Rodney J. Scott,Helen Segal,Stephan Seiler,Sudha Seshadri,Pankaj Sharma,Alan R. Shuldiner,Brian Silver,Agnieszka Slowik,Jennifer A. Smith,Martin Söderholm,Carolina Soriano,Mary J. Sparks,Tara M. Stanne,Kari Stefansson,O. Colin Stine,Konstantin Strauch,Jonathan Sturm,Cathie Sudlow,Salman M. Tajuddin,Robert L. Talbert,Turgut Tatlisumak,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteindottir,Steffen Tiedt,Matthew Traylor,Stella Trompet,Valerie Valant,Melanie Waldenberger,Matthew Walters,Liyong Wang,Sylvia Wassertheil-Smoller,David R. Weir,Kerri L. Wiggins,Stephen R. Williams,Dorota Wloch-Kopec,Daniel Woo,Rebecca Woodfield,Ona Wu,Huichun Xu,Alan B. Zonderman,Bradford B. Worrall,Paul I.W. de Bakker,Steven J. Kittner,Braxton D. Mitchell,Jonathan Rosand,Cathie L. M. Sudlow,Bradford B. Worrall,Donna K. Arnett,Oscar R. Benavente,Sylvia Wasssertheil-Smoller +202 more
TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.
Journal ArticleDOI
RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke
Steffen Tiedt,Matthias Prestel,Rainer Malik,Nicola Schieferdecker,Marco Duering,Veronika Kautzky,Ivelina Stoycheva,Julia Böck,Bernd H. Northoff,Matthias Klein,Franziska Dorn,Knut Krohn,Daniel Teupser,Arthur Liesz,Nikolaus Plesnila,Lesca M. Holdt,Martin Dichgans +16 more
TL;DR: A set of circulating microRNAs associates with acute IS and might have clinical utility as an early diagnostic marker and be superior to multimodal cranial computed tomography obtained for routine diagnostics.