C
Christophe Klopp
Researcher at Institut national de la recherche agronomique
Publications - 219
Citations - 14274
Christophe Klopp is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 44, co-authored 207 publications receiving 11088 citations. Previous affiliations of Christophe Klopp include University of Toulouse & Centre national de la recherche scientifique.
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Rapid Discovery of Mutations Responsible for Sporadic Dominant Genetic Defects in Livestock Using Genome Sequence Data: Enhancing the Value of Farm Animals as Model Species
Aurélien Capitan,Pauline Michot,François Guillaume,Cécile Grohs,Anis Djari,Sébastien Fritz,Sarah Barbey,Pauline Otz,Emmanuelle Bourneuf,Diane Esquerre,Yves Gallard,Christophe Klopp,Didier Boichard +12 more
TL;DR: The identification of candidate mutations for three dominant genetic defects (bulldog calf syndrome, glasseyed albino in Holstein and a novel neurocristopathy in Montbéliarde dairy cattle) by sequencing as few as one or two cases and using whole genome sequencing data from 526 animals from 16 different breeds as controls is reported.
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Transcription Profiling of Monocyte-Derived Macrophages Infected In Vitro With Two Strains of Streptococcus agalactiae Reveals Candidate Pathways Affecting Subclinical Mastitis in Cattle.
Anna Lewandowska-Sabat,Elena Kirsanova,Christophe Klopp,Trygve Roger Solberg,Bjørg Heringstad,Olav Østerås,Preben Boysen,Ingrid Olsaker +7 more
TL;DR: This study identified pathogen-induced regulation of key genes and pathways involved in the immune response of macrophages against infection but also likely involved in bacterial evasion of the host immune system, which may contribute to better understanding of the mechanisms underlying subclinical infection such as bovine streptococcal mastitis.
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A chromosome-level, haplotype-phased genome assembly for Vanilla planifolia highlights that partial endoreplication challenges accurate whole genome assembly
Q. Piet,Gaëtan Droc,William Marande,Gautier Sarah,Stéphanie Bocs,Christophe Klopp,Mickael Bourge,Sonja Siljak-Yakovlev,Olivier Bouchez,Céline Lopez-Roques,Sandra Lepers-Andrzejewski,Luc Bourgois,John J. Zucca,Michel Dron,Pascale Besse,Michel Grisoni,Cyril Jourda,Carine Charron +17 more
TL;DR: In this paper , the authors reported the first molecular evidence of partial endoreplication at the chromosome scale by the assembly and annotation of an accurate haplotype-phased genome of V. planifolia.
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The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most Successful Mycobacterium tuberculosis Strain in Aragon Using Whole-Genome Sequencing
Jessica Comín,Jan Madacki,Isabel Rabanaque,María Zúñiga-Antón,Daniel Ibarz,Alberto Cebollada,Jesús Viñuelas,Luis Carlos Torres,J. Sahagún,Christophe Klopp,Jesús Gonzalo-Asensio,Roland Brosch,María José Iglesias,Sofía Samper +13 more
TL;DR: The main objective of this work was to analyze this outbreak and the molecular characteristics of this successful strain, MtZ, which consists of several SNPs in genes related to virulence, pathogenesis, and survival, as well as other genomic polymorphisms, which may be implicated in its success among the authors' population.
Posted ContentDOI
Evolution of gene expression after whole-genome duplication: new insights from the spotted gar genome
Jeremy Pasquier,Ingo Braasch,Peter Batzel,Cédric Cabau,Jérôme Montfort,Thuy Thao Vi Nguyen,Elodie Jouanno,Camille Berthelot,Christophe Klopp,Laurent Journot,John H. Postlethwait,Yann Guiguen,Julien Bobe +12 more
TL;DR: It is shown that most TGD duplicates gained their current status relatively rapidly after TGD, and novel cases of TGD ohnolog subfunctionalization and neofunctionalization are reported that further illustrate the importance of these processes.