Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.
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TLDR
The crystal structure of STING bound to 2'3'-cGAMP revealed the structural basis of this high-affinity binding and a ligand-induced conformational change in STING that may underlie its activation, and showed that endogenous cGAMP in mammalian cells contains two distinct phosphodiester linkages.About:
This article is published in Molecular Cell.The article was published on 2013-07-25 and is currently open access. It has received 782 citations till now. The article focuses on the topics: Cyclic GMP-AMP synthase & Phosphodiester bond.read more
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Interferon-Stimulated Genes: A Complex Web of Host Defenses
TL;DR: This review begins by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production and describes ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the Jak-STAT pathway.
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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng,Hua Liang,Meng Xu,Xuanming Yang,Byron Burnette,Ainhoa Arina,Xiao Dong Li,Helena J. Mauceri,Michael A. Beckett,Thomas E. Darga,Xiaona Huang,Thomas F. Gajewski,Zhijian J. Chen,Yang Xin Fu,Ralph R. Weichselbaum +14 more
TL;DR: Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy.
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
TL;DR: Recent advances in understanding of the cGAS–STING pathway are reviewed, focusing on the regulatory mechanisms and roles of this pathway in heath and disease.
Journal ArticleDOI
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
Leticia Corrales,Laura Hix Glickman,Sarah M. McWhirter,David B. Kanne,Kelsey E. Sivick,George E. Katibah,Seng-Ryong Woo,Edward E. Lemmens,Tamara Banda,Justin Leong,Ken Metchette,Thomas W. Dubensky,Thomas F. Gajewski +12 more
TL;DR: It injection of STING agonists induced profound regression of established tumors in mice and generated substantial systemic immune responses capable of rejecting distant metastases and providing long-lived immunologic memory.
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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Jiaxi Wu,Zhijian J. Chen +1 more
TL;DR: Recent advances in understanding the mechanism of nucleic acid sensing and signaling in the cytosol of mammalian cells as well as the emerging role of cytosolic nucleic acids in autoimmunity are reviewed.
References
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