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Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Combining growth factors, stem cells, and gene therapy for the aging brain.
TL;DR: Human neural stem cells are ideal for ex vivo gene therapy, and may be used in the future as "minipumps" to release GDNF in vivo to protect aging neurons, and delay the effects of aging in the brain, giving a better quality of life.
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Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells.
Pamela Milani,Renan Escalante-Chong,Brandon Shelley,Natasha L. Patel-Murray,Xiaofeng Xin,Miriam Adam,Berhan Mandefro,Berhan Mandefro,Dhruv Sareen,Dhruv Sareen,Clive N. Svendsen,Clive N. Svendsen,Ernest Fraenkel +12 more
TL;DR: In this paper, the authors developed a protocol for freezing neuronal cells that is compatible with ATAC-Seq; they focused on a disease-relevant cell type, namely motor neurons differentiated from induced pluripotent stem cells (iMNs) from a patient affected by spinal muscular atrophy.
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Regenerative cellular therapies for neurologic diseases.
TL;DR: This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's Disease, macular degeneration and peripheral nerve diseases.
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Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Amanda J. Kedaigle,Ernest Fraenkel,Ranjit Singh Atwal,Min Wu,James F. Gusella,Marcy E. MacDonald,Julia A. Kaye,Steven Finkbeiner,Virginia B. Mattis,Colton M Tom,Clive N. Svendsen,Alvin R. King,Yumay Chen,Jennifer Stocksdale,Ryan G. Lim,Malcolm Casale,Ping H Wang,Leslie M. Thompson,Sergey S Akimov,Tamara Ratovitski,Nicolas Arbez,Christopher A. Ross +21 more
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Modeling Huntington׳s disease with patient-derived neurons
TL;DR: This review covers disease modeling in vitro and, via chimeric animal generation, in vivo using human HD patient MSNs differentiated from embryonic stem cells or induced pluripotent stem cells, the established phenotypes found in cell-based models and transplantation studies using these cells.