C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Growth factors regulate the survival and fate of cells derived from human neurospheres
Maeve A. Caldwell,Xiaoling He,Neil Wilkie,Scott J. Pollack,George R. Marshall,Keith A. Wafford,Clive N. Svendsen,Clive N. Svendsen +7 more
TL;DR: It is shown that maintaining cell–cell contact during the differentiation stage, in combination with growth factor administration, can increase the number of neurons generated under serum-free conditions from 8% to >60%.
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Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System
TL;DR: Results show that purified populations of rat or human EGF-responsive CNS stem cells do not form large graft masses or migrate extensively into the surrounding host tissues when transplanted into the adult striatum, however, modifications of the growth conditions in vitro may lead to an improvement of their survival in vivo.
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Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
Thor Ostenfeld,Maeve A. Caldwell,Karen R. Prowse,Maarten H.K. Linskens,Eric Jauniaux,Clive N. Svendsen +5 more
TL;DR: It is shown that human neural precursor cells express very low levels of telomerase at early passages, but that this decreases to undetectable levels at later passages, which may provide the ideal basis for the repair of other lesions of the CNS where extensive axonal outgrowth is required.
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Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Gad D. Vatine,Gad D. Vatine,Riccardo Barrile,Michael J. Workman,Samuel Sances,Bianca K. Barriga,Matthew Rahnama,Sonalee Barthakur,Magdalena Kasendra,Carolina Lucchesi,Jordan Kerns,Norman Wen,Weston R. Spivia,Zhaohui Chen,Jennifer E. Van Eyk,Clive N. Svendsen +15 more
TL;DR: A neurovascular unit is created that recapitulates complex BBB functions, provides a platform for modeling inheritable neurological disorders, and advances drug screening, as well as personalized medicine.
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Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.
Robert H. Andres,Nobutaka Horie,William Slikker,Hadar Keren-Gill,Ke Zhan,Guohua Sun,Nathan C. Manley,Marta P. Pereira,Lamiya A. Sheikh,Erin McMillan,Bruce T. Schaar,Clive N. Svendsen,Tonya M. Bliss,Gary K. Steinberg +13 more
TL;DR: The results show the first evidence that human neural progenitor cell treatment can significantly increase dendritic plasticity in both the ipsi- and contralesional cortex and this coincides with stem cell-induced functional recovery, and postulate that human neurons aid recovery after stroke through secretion of factors that enhance brain repair and plasticity.