C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.
Dan Krakora,Patrick L. Mulcrone,Michael M. Meyer,Christina M. Lewis,Ksenija Bernau,Genevieve Gowing,Genevieve Gowing,Chad Zimprich,Patrick Aebischer,Clive N. Svendsen,Clive N. Svendsen,Masatoshi Suzuki +11 more
TL;DR: A combined ex vivo delivery of GDNF and VEGF in extending survival and protecting neuromuscular junctions and motor neurons showed a strong synergistic effect, which further support ex vivo gene therapy approaches for ALS that target skeletal muscle.
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Restricted growth potential of rat neural precursors as compared to mouse.
TL;DR: Fibroblast growth factor-2 (FGF-2) alone did not lead to an expansion in rat striatal precursor cell number under the conditions used here, and EGF combined with FGF-1 acted synergistically on cell growth, but did not prevent the final senescence and death of the rat precursors.
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Glutamate enhances proliferation and neurogenesis in human neural progenitor cell cultures derived from the fetal cortex.
Masatoshi Suzuki,Aaron D. Nelson,Joshua B. Eickstaedt,Kyle Wallace,Lynda S. Wright,Clive N. Svendsen +5 more
TL;DR: It is shown that glutamate can significantly increase the proliferation rates of human neural progenitor cells (hNPC), and whether the glutamate‐responsive hNPC had an increased potential for neurogenesis is found, and it is suggested that glutamate stimulates the division of human progenitors cells with neurogenic potential.
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EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs
Allison D. Ebert,Brandon Shelley,Amanda M. Hurley,Marco Onorati,Valentina Castiglioni,Teresa N. Patitucci,Soshana P. Svendsen,Virginia B. Mattis,Jered V. McGivern,Andrew J. Schwab,Dhruv Sareen,Ho Won Kim,Elena Cattaneo,Clive N. Svendsen +13 more
TL;DR: A simple method to generate and expand multipotent, self-renewing pre-rosette neural stem cells from both human embryonic stem cells and human induced pluripotent stem cells without utilizing embryoid body formation, manual selection techniques, or complex combinations of small molecules is developed.
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Induced pluripotent stem cells: a new revolution for clinical neurology?
TL;DR: An exciting new avenue for neurological research and drug development is the discovery that patients' somatic cells can be reprogrammed to a pluripotent state; these cells are known as induced pluripotency stem cells.