C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support
Veronica J. Garcia,David Rushton,Colton M Tom,Nicholas D. Allen,Paul J. Kemp,Clive N. Svendsen,Virginia B. Mattis +6 more
TL;DR: This iPSC-based HD model demonstrates the critical effects of mtHTT on human astrocytes, which not only broadens the understanding of disease susceptibility beyond cortical and striatal neurons but also increases potential drug targets.
Journal ArticleDOI
Regional potential for oligodendrocyte generation in the rodent embryonic spinal cord following exposure to EGF and FGF-2
TL;DR: It is confirmed that significant numbers of oligodendrocytes and their immediate (A2B5+) precursors are present only in the ventral spinal cord of the E14 rodent, but following exposure to EGF and FGF‐2, significant numbers also develop from isolated E14 dorsal derived cells without interaction from the vental spinal cord.
Posted ContentDOI
Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell Lines
Jeffrey D. Rothstein,James D. Berry,Clive N. Svendsen,Leslie M. Thompson,Steven Finkbeiner,Jennifer E. Van Eyk,Ernest Fraenkel,Merit Cudkowicz,Nicholas J. Maragakis,Dhruv Sareen,Raquel Norel,Victoria Dardov,Alyssa N. Coyne,Aaron T. Frank,Andrea Matlock,Rakhi Pandey,Vineet Vibhav,Leandro Lima,Jie Wu,Divya Ramamoorthy,Ryan Lim,Julia A. Kaye,Jonathan Z. Li,Terri G. Thompson,Emily G. Baxi,Answer Als +25 more
TL;DR: This community based clinical and science program provides for the identification of distinct reliably identifiable subgroups among the sporadic and familial patients and the great utility in iPS based approaches to disease pathophysiology and therapy discovery.
Journal ArticleDOI
Huntington's disease: animal models and transplantation repair
TL;DR: Recent advances in the development of improved animal models of Huntington's disease and strategies for its repair are reviewed, indicating the prospect of viable strategies for structural repair in this disorder.
Book ChapterDOI
Ex vivo gene therapy for the treatment of neurological disorders.
TL;DR: Given the current outcomes from researchers and clinical trials, along with exciting new developments in ex vivo gene and cell therapy, it is anticipated that successful treatments for neurological diseases will arise in the near future.